image

leslie-chan-probes-in-gut.jpg

Primary tabs

An AI image generated using Google Gemini depicts white ingested probes release gaseous reporters after sensing the activity of GUS (in purple), an enzyme produced by the gut microbiome (tan) that is responsible for unwanted drug side effects (i.e., gastrointestinal toxicity). After release, the gaseous reporters rapidly traffic to the lungs for exhalation, enabling measurement of intestinal GUS activity via simple breath analysis. Thus, ingestible probes enable use of breath tests to predict and manage pos