(09-0302) Prof. Richard Caprioli, Vanderbilt Univ School of Medicine

Event Details
  • Date/Time:
    • Monday March 2, 2009
      2:00 pm - 3:00 pm
  • Location: G011 MS&E Bldg
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Shirley Tomes
Chemistry & Biochemistry
Contact Shirley Tomes
404-894-0591
Summaries

Summary Sentence: Prof. Richard Caprioli, Vanderbilt Univ School of Medicine

Full Summary: Prof. Richard Caprioli, Vanderbilt University School of Medicine Using a Mass Spectrometer as a Camera: Molecular Images of Tissues in Biological and Clinical Research Peter B. Sherry Lecture

Prof. Richard Caprioli, Vanderbilt University School of Medicine

Using a Mass Spectrometer as a Camera: Molecular Images of Tissues in Biological and Clinical Research

Peter B. Sherry Lecture

Molecular processes that occur in cells and tissues take place in specific areas and sometimes only at certain times. These spatial and temporal changes are an important aspect for our understanding of how cells work and for life processes in general. There are many technologies that can be used to measure molecules in such samples but perhaps the most specific is mass spectrometry in its molecular specificity, high sensitivity, and high throughput. This seminar will discuss the use of laser based ionization mass spectrometry for the measurement of the molecular distribution of proteins, peptides, lipids, metabolites and drugs within tissue specimens.

Several biological applications of this technology will be discussed, including examples of the discovery of unique molecular processes in mouse developmental models and the profiling of human tumors, characterizing protein differences between tumor grades, and monitoring protein changes due to drug therapy. This technology has also been applied to the creation of 3-D protein images of substructures of mouse brain, to drug targeting and metabolic studies and the measurement of concomitant protein changes in specific tissues after systemic drug administration. Finally, we explore the correlation of lipid and protein changes in several systems in both health and disease.

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School of Chemistry and Biochemistry

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Seminar/Lecture/Colloquium
Keywords
physical chemistry
Status
  • Created By: Shirley Tomes
  • Workflow Status: Published
  • Created On: Jan 28, 2009 - 8:00pm
  • Last Updated: Oct 7, 2016 - 9:57pm