(11-0421) Prof. Tadhg Begley, Texas A&M University

Event Details
  • Date/Time:
    • Thursday April 21, 2011 - Friday April 22, 2011
      4:00 pm - 4:59 pm
  • Location: MoSE G011
  • Phone:
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  • Fee(s):
    N/A
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Contact
Shirley Tomes
Chemistry & Biochemistry
Contact Shirley Tomes
404-894-0591
Summaries

Summary Sentence: Prof. Tadhg Begley, Texas A&M University

Full Summary: Prof. Tadhg Begley, Texas A&M University Thiamin biosynthesis: characterization of two genes of unknown function School Colloquia

Prof. Tadhg Begley, Texas A&M University

Thiamin biosynthesis: characterization of two genes of unknown function

School Colloquia

Thiamin pyrophosphate plays a key role in the stabilization of the acyl carbanion biosynthon in carbohydrate and amino acid metabolism and is an essential cofactor in all living systems. The biosyntheses of the thiamin pyrimidine and thiazole are complex and differ from any of the characterized chemical or biochemical routes to these heterocycles. The complete thiamin biosynthesis has now been reconstituted in a biochemically-defined system and the structures of all of the biosynthetic enzymes have been determined. Our mechanistic understanding of the pathway is also at an advanced stage.

This presentation will describe recent progress on the functional characterization of the TenA and TenI genes involved in thiamin biosynthesis.

For more information contact Prof. Wendy Kelly (404-385-1154).

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School of Chemistry and Biochemistry

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Categories
Seminar/Lecture/Colloquium
Keywords
physical chemistry
Status
  • Created By: Shirley Tomes
  • Workflow Status: Published
  • Created On: Feb 8, 2010 - 8:00pm
  • Last Updated: Oct 7, 2016 - 9:48pm