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(11-0505) Prof. Lillian Chong, University of Pittsburgh
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Prof. Lillian Chong, University of Pittsburgh
Molecular simulations of protein binding and switching
Physical Chemistry Seminar Series
A major challenge in the field of biomolecular simulations is to access the long-timescale dynamics of biologically relevant protein motions such as the relative motions of protein domains and allosteric transitions. My group uses a variety of approaches for providing detailed views of such motions that might aid the design of molecular sensors or therapeutics. In this talk, I will present recent applications to the simulation of large-scale conformational changes in bi-functional, two-domain protein switches, molecular association kinetics, and how nature might correct for âmistakesâ in binding geometry for a model protein-peptide complex.
For more information contact Prof. Rigoberto Hernandez (404-894-0594) or Prof. Raquel Lieberman (404-385-3663).
Status
- Workflow Status:Published
- Created By:Shirley Tomes
- Created:09/14/2010
- Modified By:Fletcher Moore
- Modified:10/07/2016
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