Peter J. Yang - PhD Defense Presentation

Event Details
  • Date/Time:
    • Monday October 10, 2011
      1:30 pm - 3:00 pm
  • Location: Mason Building, Rm 142A
  • Phone:
  • URL:
  • Email: chris.ruffin@ibb.gatech.edu
  • Fee(s):
    N/A
  • Extras:
Contact

Chris Ruffin

Summaries

Summary Sentence: "Incorporation of Protease-Sensitive Biomaterial Degradation and Tensile Strain For Applications in Ligament-Bone Interface Tissue Engineering"

Full Summary: Peter J. Yang - PhD Defense Presentation
"Incorporation of Protease-Sensitive Biomaterial Degradation and Tensile Strain For Applications in Ligament-Bone Interface Tissue Engineering"

"Incorporation of Protease-Sensitive Biomaterial Degradation and Tensile Strain For Applications in Ligament-Bone Interface Tissue Engineering"

Advisor: Johnna S. Temenoff, Ph.D. (Biomedical Engineering)

Committee:
Thomas H. Barker, Ph.D. (Georgia Tech)
Andrés J. García, Ph.D. (Georgia Tech)
Robert E. Guldberg, Ph.D. (Georgia Tech)
Marc E. Levenston, Ph.D. (Stanford University)

The interface between tendon/ligament and bone tissue is a complex transition of biochemical, cellular and mechanical properties. Investigating computational and tissue engineering models that imitate aspects of this interface may supply critical design parameters for designing future tissue replacements to promote increased biochemical and mechanical integration between tendon/ligament and bone. Strategies for modeling this tissue have typically focused on the development of heterogeneous structures to create gradients or multiphasic materials that mimic aspects of the transition. However, further work is required to elucidate the role of specific mechanical and material stimuli in recapitulating features of the tendon/ligament-bone insertion. In particular, in constructs that exhibit variation in both mechanical and biochemical properties, the interplay of mechanical, material, and chemical signals can complicate understanding of the particular factors at work in interface formation. Thus, the overall goal of this dissertation was to provide insight into the role of mechanical strain and scaffold degradability on cell behavior within heterogeneous biomaterials.

Specifically, a method for tracking cell movement within a degradable gel through a laminated interface was developed. A computational model was created to examine possible variation in local mechanical strain due to heterogeneity in mechanical properties and different interface geometries. Finally, the influence of biomaterial degradability on changes in encapsulated human mesenchymal stem cell (MSC) morphology under response to cyclic mechanical strain was explored. Together, these studies provide insight into mechanical and material design considerations when devising tissue engineering strategies to regenerate the tendon/ligament-bone interface.

Additional Information

In Campus Calendar
No
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Bioengineering Graduate Program

Invited Audience
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Categories
Other/Miscellaneous
Keywords
bioengineering, Incorporation of Protease-Sensitive Biomaterial Degradation and Tensile Strain For Applications in Ligament-Bone Interface Tissue Engineering  , Peter Yang
Status
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Sep 27, 2011 - 6:50am
  • Last Updated: Oct 7, 2016 - 9:55pm