BIOE Seminar Series

Event Details
Contact

Host:  Hanjoong Jo, PhD

Summaries

Summary Sentence: "Mechanotransduction and Mechanotransmission by Cell Adhesion Receptors during Atherogenesis" - Martin Schwartz, PhD - Yale University

Full Summary: BIOE Seminar SeriesMartin Schwartz, PhD - Yale University

Media
  • Martin Schwartz, PhD - University of Virginia Martin Schwartz, PhD - University of Virginia
    (image/jpeg)

""Mechanotransduction and Mechanotransmission by Cell Adhesion Receptors during Atherogenesis"

Martin Schwartz, PhD
- Yale University

Abstract:
Atherosclerosis is an inflammatory disease that occurs mainly in regions of arteries that are subject to disturbances in fluid flow, whereas regions subject to high laminar shear are protected from inflammation.  We identified a complex of proteins at endothelial cell-cell junctions that transduce forces from flow to activate signaling pathways in the cell.  These pathways activate integrins at the basal surface of the cell, which then bind to extracellular matrix and activate further signals.  I will discuss the role of integrins and extracellular matrix in inflammatory effects of flow. I will also present recent work measuring forces across cell-cell junctional molecules to elucidate molecular mechanisms of mechanotransduction.

 

The Bioengineering Seminar Series is a joint seminar series between IBB and the BME department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in IBB room 1128 unless otherwise indicated.

Related Links

Additional Information

In Campus Calendar
No
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
No audiences were selected.
Categories
Seminar/Lecture/Colloquium
Keywords
Atherogenesis, BioE Seminar, Cell Adhesion Receptors, IBB, Martin Schwartz, Mechanotransduction, Mechanotransmission
Status
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Jun 13, 2011 - 6:53am
  • Last Updated: Oct 7, 2016 - 9:55pm