GaP Seminar - The Multiple Personalities of Doxorubicin: An Examination of Redox Regulation in Cancer Treatment

Event Details
Contact

Manu Platt

Summaries

Summary Sentence: Nenna Finn

Full Summary: GaP Seminar SeriesNnenna Finn - "The Multiple Personalities of Doxorubicin: An Examination of Redox Regulation in Cancer Treatment"

 Nnenna Finn 

Advisor:  Melissa L. Kemp

Abstract:

Doxorubicin is a well known chemotherapeutic agent used in the treatment of a variety of cancers. Previous research has identified most of the components that comprise the doxorubicin bioactivation network; however, adaptation of the network to changes in doxorubicin treatment or to patient-specific changes in network components is much less understood. We present a model of doxorubicin bioactivation in leukemia cells that illustrates the dual-nature of doxorubicin treatment, and highlights pharmacological intervention strategies for promoting or impeding doxorubicin-induced cytotoxicity in cancer cells.

 

Additional Information

In Campus Calendar
No
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
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Categories
Seminar/Lecture/Colloquium
Keywords
GaP Seminar Series, IBB
Status
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Apr 12, 2011 - 6:39am
  • Last Updated: Oct 7, 2016 - 9:54pm