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GaP Seminar - The Multiple Personalities of Doxorubicin: An Examination of Redox Regulation in Cancer Treatment
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Nnenna Finn
Advisor: Melissa L. Kemp
Abstract:
Doxorubicin is a well known chemotherapeutic agent used in the treatment of a variety of cancers. Previous research has identified most of the components that comprise the doxorubicin bioactivation network; however, adaptation of the network to changes in doxorubicin treatment or to patient-specific changes in network components is much less understood. We present a model of doxorubicin bioactivation in leukemia cells that illustrates the dual-nature of doxorubicin treatment, and highlights pharmacological intervention strategies for promoting or impeding doxorubicin-induced cytotoxicity in cancer cells.
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- Workflow Status:Published
- Created By:Colly Mitchell
- Created:04/12/2011
- Modified By:Fletcher Moore
- Modified:10/07/2016
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