Dicing and Beyond: Regulatory RNA in Humans and Bacteria

Event Details
Contact

Jessica Gilmore

Summaries

Summary Sentence: Jennifer A. Doudna, PhD - University of California, Berkeley

Full Summary: CSSB Distinguished Lecturer Series Jennifer A. Doudna, PhD - Howard Hughes Investigator and Professor of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley"Dicing and Beyond: Regulatory RNA in Humans and Bacteria"

CSSB Distinguished Lecturer Series

Abstract:
In eukaryotic cells, small RNA molecules regulate the expression of many genes. The enzyme Dicer plays a central role in producing these RNAs and ensuring that they assemble with other proteins into effector complexes. Recent findings show that Dicer and its partner RNA binding proteins can alter miRNA processing to change the set of mRNAs targeted for silencing. Although Dicer homologs do not occur in prokaryotic cells, bacteria possess distinct sets of enzymes that produce short RNA molecules to block the propagation of viral and plasmid sequences. In bacteria, these regulatory RNAs are produced from clustered regularly interspaced short palindromic repeats (CRISPRs). I will discuss our recent work to uncover the molecular basis for small RNA production and targeting. We also find interesting similarities in the thermodynamics of target recognition between RNAi-type and CRISPR-type systems.

Additional Info:
Research Interests: RNA molecules are uniquely capable of encoding and controlling the expression of genetic information, often as a consequence of their three-dimensional structures. We are interested in understanding RNA-mediated initiation of protein synthesis, and RNA-protein complexes involved in targeting proteins for export out of cells. We are also investigating the early steps in gene regulation by RNA interference.

Jeffrey Skolnick - faculty host

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In Campus Calendar
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Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

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Categories
Seminar/Lecture/Colloquium
Keywords
CSSB, Dicing and Beyond: Regulatory RNA in Humans and Bacteria, Georgia Tech, Jeffrey Skolnick
Status
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Feb 23, 2011 - 6:01am
  • Last Updated: Oct 7, 2016 - 9:54pm