Bioengineering Seminar Series

Event Details
  • Date/Time:
    • Tuesday April 13, 2021
      11:00 am - 12:00 pm
  • Location: Virtual Seminar
  • Phone:
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

Andrés García, Ph.D. - faculty host
Rose Brito - event inquiries

Summaries

Summary Sentence: Zhen Ma, Ph.D., Syracuse University

Full Summary: No summary paragraph submitted.

Media
  • Bioengineering Seminar Series Bioengineering Seminar Series
    (image/png)

VIRTUAL EVENT

Zhen Ma, Ph.D.
Assistant Professor
Carol and Samuel Nappi Research Scholar
Department of Biomedical & Chemical Engineering
Syracuse Biomaterials Institute
Syracuse Soft & Living Matters 
Syracuse University


PARTICIPATION LINK

There is an urgent need for in vitro models that can recapitulate the cardiac developmental process and can be used to study the drug effects on cardiac developmental stages and potentially overall fetus health. We develop the first in vitro model to mimic the early developing human heart, which helps us screen for drugs likely to generate to cardiac birth defects using a high-content system. We use our cell-patterning method to present biophysical cues during the hiPSC cardiac differentiation to generate 3D ventricle-like cardiac microchambers that mimic early developing hearts. We envisage that this in vitro model of human early heart development would be a pioneering breakthrough in drug discovery, regulation, and prescription for safe pregnancy and fetus development.

The integration of complex in vitro cardiac tissue models with human induced pluripotent stem (hiPS) cells and genome editing tools has been shown to enhance the physiological phenotype, improve cardiomyocyte (CMs) maturity, and recapitulate disease pathologies. We establish cardiac tissue models populated with healthy wild-type hiPS-CMs and genome-engineered isogenic diseased hiPS-CMs. Gene-editing techniques allow us to interrogate specific gene mutations with isogenic control, and engineered systems allow us mimicking the in vivo tissue architecture and modulating the environmental stress. This in-vivo mimicked stem cell-derived cardiac microtissue platform could be useful for identifying the genetic and environmental basis of human cardiomyopathies, and screen potential drug candidates for treatment.

The Bioengineering Seminar Series is co-hosted by the Parker H. Petit Institute for Bioengineering and Bioscience, and the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.

 

Related Links

Additional Information

In Campus Calendar
Yes
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Faculty/Staff, Postdoc, Public, Graduate students, Undergraduate students
Categories
Seminar/Lecture/Colloquium
Keywords
IBB, BioE Seminar
Status
  • Created By: Rose Brito
  • Workflow Status: Published
  • Created On: Dec 2, 2020 - 4:57pm
  • Last Updated: Dec 11, 2020 - 7:48am