Researchers Describe First Functioning "Lipidome" of Mouse Macrophage

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Researchers Describe First Functioning "Lipidome" of Mouse Macrophage

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For the first time, scientists have described not only the identities and quantities of fat species in a living mammalian cell - in this case, a mouse macrophage or white blood cell - but they also report how these lipids react and change over time to a bacterial stimulus triggering the cell’s immune response.

For the first time, scientists have described not only the identities and quantities of fat species in a living mammalian cell - in this case, a mouse macrophage or white blood cell - but they also report how these lipids react and change over time to a bacterial stimulus triggering the cell's immune response.

Writing in the December 17 issue of the /Journal of Biological Chemistry/, lead author Edward A. Dennis, PhD, distinguished professor of pharmacology, chemistry and biochemistry at the University of California San Diego School of Medicine, said the work culminates more than seven years of effort by scientists in LIPID MAPS, a national consortium of 12 research laboratories at nine "core" universities, medical research institutes and life sciences companies collaborating to study the structure and function of lipids. The laboratory of Dr. Al Merrill (School of Biology, Georgia Tech) was responsible for the sphingolipid analyses and characterization carried out by the consortium.

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Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

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Institute and Campus, Chemistry and Chemical Engineering, Student and Faculty, Engineering, Life Sciences and Biology, Nanotechnology and Nanoscience, Research, Physics and Physical Sciences
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Keywords
Al Merrill, Biology, Georgia Tech, IBB
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  • Created By: Floyd Wood
  • Workflow Status: Published
  • Created On: Jan 2, 2011 - 8:00pm
  • Last Updated: Oct 7, 2016 - 11:08pm