BME Seminar with Quinton Smith, Ph.D.*

Event Details
  • Date/Time:
    • Thursday February 6, 2020
      11:15 am - 12:15 pm
  • Location: Emory, HSRB, Room E160: Videoconference Georgia Tech – UAW 3115 / Stream from PC:
  • Phone:
  • URL:
  • Email:
  • Fee(s):
  • Extras:

Walter Rich


Summary Sentence: Stem Cell Fate is a Touchy Subject

Full Summary: No summary paragraph submitted.

Quinton Smith, Ph.D.*
Postdoctoral Fellow
Koch Institute for Integrative Cancer Research at MIT


"Stem Cell Fate is a Touchy Subject"


Physical cues are crucial to embryonic development, morphogenic events, and tissue organization, but methods to differentiate cells from human induced pluripotent stem cells (hiPSCs) mainly rely on chemical cues.  As such, the role of substrate stiffness, fluid shear stress, and confinement were interrogated on stem cell derived endothelial cell differentiation efficiency and functionality. We find priming hiPSCs on compliant substrates, as opposed to traditionally used rigid plastic surfaces, promotes efficient endothelial specification in the absence of growth factor supplementation.  Leveraging micropatterned domains, which restrict extracellular matrix accessibility, also enhances endothelial specification and early lineage organization. Finally, using a microfluidic platform, we find that primary cilia, a microtubule-based mechanosensor, is crucial to stem cell derived endothelial shear response. Collectively, we can investigate the role of biophysical stimuli on cell fate and function using a variety of engineering tools.

Quinton Smith received his Ph.D. in Chemical and Biomolecular Engineering from Johns Hopkins University in 2017 after completing his bachelor’s degree in Chemical Engineering from the University of New Mexico.  As a graduate student under the guidance of Dr. Sharon Gerecht, he implemented various tools to explore the roles of physical and chemical stimuli on stem cell lineage specification and downstream vascular maturation.  Dr. Smith is currently a postdoctoral fellow under the mentorship of Dr. Sangeeta Bhatia at MIT’s Koch Institute for Integrative Cancer Research.  Here, he is investigating the role of the biliary epithelium in liver regeneration. Dr. Smith’s predoctoral work was supported by an NIH/NHLBI F-31 and NSF Graduate Research Fellowship. He is a recipient of the 2017 Siebel Scholar award and joined the class of 2018 HHMI Hanna Gray Fellows.

Host: Sakis Mantalaris


Thursday, February 6
11:15 am - 12:15 pm
Emory HSRB bldg, E160

Video Conference: Whitaker 3115

Bluejeans Meeting ID
1.)To join the Meeting:
To join via phone, dial:
+1.408.740.7256 (US (San Jose))
+1.888.240.2560 (US Toll Free)
+1.408.317.9253 (US (Primary, San Jose))
(see all numbers -
 2) Enter Conference ID : 809 850 842



Additional Information

In Campus Calendar

Wallace H. Coulter Dept. of Biomedical Engineering

Invited Audience
Faculty/Staff, Public, Undergraduate students
  • Created By: Walter Rich
  • Workflow Status: Published
  • Created On: Jan 10, 2020 - 11:25am
  • Last Updated: Jan 10, 2020 - 11:28am