Muhibullah S Tora

BME PhD Thesis Proposal Presentation

Date: January 17th, 2020

Time: 2:00 PM

Location: WMRB 5101

Committee Members:

Nicholas M Boulis, MD (Georgia Tech/Emory, Department of Biomedical Engineering) (Advisor)

John N Oshinski, PhD (Georgia Tech/Emory, Department of Biomedical Engineering)

Robert Gross, MD, PhD (Georgia Tech/Emory, Department of Biomedical Engineering)

Steven Sloan, MD, PhD (Emory University, Department of Genetics)

Peter Canoll, MD PhD (Columbia University, Department of Pathology)

Title: Development of a Novel Porcine Disease Model of Glioma

Summary: Whether in the brain or spinal cord, high-grade gliomas have a clinical picture of untenable morbidity and mortality. In part, this represents a disease process that is refractory to various treatment approaches. On the other hand, this raises the question of the translational value of current models. In the present research proposal, a pathway to the development of a novel and immunocompetent large animal model of high-grade glioma in the brain and spinal cord is described. Here it is proposed to utilize lentiviral gene transfer to the porcine central nervous system to induce the formation of high-grade gliomas with subsequent radiologic, immunohistochemical, inflammatory, and transcriptomic characterization.