PhD Proposal by Matthew Cribb

Event Details
  • Date/Time:
    • Tuesday November 27, 2018
      2:00 pm - 4:00 pm
  • Location: EBB Room 4029
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Summaries

Summary Sentence: The role of leukotriene B4 in driving lymphatic failure in lymphedema

Full Summary: No summary paragraph submitted.

Matthew Cribb

BioE Ph.D. Proposal Presentation

Tuesday, November 27th, 2018 | 2:00 pm

EBB Room 4029

 

Advisor:

J. Brandon Dixon, Ph.D. (Georgia Institute of Technology)

 

Committee:

Krishnendu Roy, Ph.D. (Georgia Institute of Technology)

Rudolph Gleason, Ph.D. (Georgia Institute of Technology)

Fredrik Vannberg, Ph.D. (Georgia Institute of Technology)

Mark Nicolls, M.D. (Stanford University School of Medicine)

 

The role of leukotriene B4 in driving lymphatic failure in lymphedema

 

Lymphedema is a devastating disease that predominantly affects breast cancer patients post-surgery, leading to swelling at the extremities and tissue fibrosis. There are currently no pharmacological treatments available for lymphedema. However, LTB4, a metabolite of arachidonic acid, has been implicated in the development of lymphedema and identified as a possible drug target. The objective of this study is to determine if LTB4 drives lymphatic collecting vessel failure. The hypothesis is that LTB4 inhibits lymphatic collecting vessel contraction at high concentrations occurring post-injury, leading to lymphatic failure. We predict that this functional effect of LTB4 occurs through two mechanisms; LTB4 directly acts on lymphatic collecting vessels to inhibit pumping and LTB4 drives macrophage recruitment to the site of injury. First, we will test LTB4’s direct effect on lymphatic collecting vessel contractility. Next, an LTB4 antagonist will be used to treat mice induced with lymphedema to study how LTB4 affects collecting vessel function during disease progression. A genetic macrophage depletion mouse model will be used to examine if there is a macrophage-mediated effect of LTB4 on collecting vessel pump function during lymphedema development. The results of this study will help identify multiple mechanisms by which LTB4 drives lymphatic collecting vessel pump failure.

Additional Information

In Campus Calendar
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Groups

Graduate Studies

Invited Audience
Faculty/Staff, Public, Graduate students, Undergraduate students
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Other/Miscellaneous
Keywords
Phd proposal
Status
  • Created By: Tatianna Richardson
  • Workflow Status: Published
  • Created On: Nov 14, 2018 - 8:48am
  • Last Updated: Nov 14, 2018 - 8:48am