Breakfast Club Seminar

Event Details
  • Date/Time:
    • Tuesday February 12, 2019
      8:30 am - 9:30 am
  • Location: Parker H. Petit Institute for Bioengineering & Bioscience, Suddath Seminar Room 1128
  • Phone: 4048946228
  • URL: Petit Institute website
  • Email: connect@ibb.gatech.edu
  • Fee(s):
    N/A
  • Extras:
Contact

Colly Mitchell - Events Manager

Summaries

Summary Sentence: "RNA Profiling: Extracting Structural Signals from Noisy Distributions" - Christine Heitsch, Ph.D. - Georgia Tech

Full Summary: No summary paragraph submitted.

Media
  • Petit Institute Breakfast Club Seminar Series Petit Institute Breakfast Club Seminar Series
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"RNA Profiling: Extracting Structural Signals from Noisy Distributions"

Christine Heitsch, Ph.D.
Professor, School of Mathematics
Georgia Tech


Accurate RNA structural prediction remains challenging, despite its increasing biomedical importance.  Sampling secondary structures from the Gibbs distribution yields a strong signal of high probability base pairs.  However, identifying higher order substructures requires further analysis.  Profiling (Rogers & Heitsch, NAR, 2014) is a novel method which identifies the most probable combinations of base pairs across the Boltzmann ensemble.  This combinatorial approach is straightforward, stable, and clearly separates structural signal from thermodynamic noise.  Moreover, it can be extended to predict consensus stems for an RNA family with high accuracy via unsupervised clustering of unaligned homologous sequences.

Related Links

Additional Information

In Campus Calendar
Yes
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Wallace H. Coulter Dept. of Biomedical Engineering

Invited Audience
Faculty/Staff, Postdoc, Public, Graduate students, Undergraduate students
Categories
Seminar/Lecture/Colloquium
Keywords
IBB, BK Club
Status
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Nov 5, 2018 - 7:31am
  • Last Updated: Nov 5, 2018 - 7:31am