PhD Proposal by Angel J. Santiago-Lopez

Event Details
  • Date/Time:
    • Wednesday October 3, 2018
      1:00 pm - 3:00 pm
  • Location: Whitaker Rm 2110
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Summaries

Summary Sentence: Development of a gene therapy for unfolded protein regulation as a treatment for α-synucleinopathies

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Angel J. Santiago-Lopez

BioE Ph.D. Proposal Presentation

Wednesday, October 3rd, 2018 | 1:00pm

Whitaker Rm 2110

 

Advisor:

Robert E. Gross, M.D., Ph.D. (Georgia Institute of Technology/Emory University)

 

Committee:

Michelle C. LaPlaca, Ph.D. (Georgia Institute of Technology)

Mark R. Prausnitz, Ph.D. (Georgia Institute of Technology)

Jae-Kyung (Jamise) Lee, Ph.D. (University of Georgia)

Ravi S. Kane, Ph.D. (Georgia Institute of Technology)

 

Development of a gene therapy for unfolded protein regulation as a treatment for α-synucleinopathies

α-Synucleinopathies are neurodegenerative diseases characterized by intracellular inclusions of α-synuclein (α-syn) aggregates and they include conditions such as Parkinson’s Disease (PD) and Dementia with Lewy Bodies (DLB). A prevailing view is that disease-associated factors such as aging compromise the ability of neurons to efficiently clear abnormally folded proteins which leads to the formation of intracellular aggregates and neurodegeneration. While enhancing the clearance of misfolded α-syn is a potential therapeutic strategy for PD, current methods to activate cellular mechanisms for protein degradation rely mostly on pharmacological inducers or “once-and-done” gene delivery interventions. A translational roadblock in these approaches is the lack of control over dosage, the precise time of intervention, and undesirable effects associated with the broad and sustained activation of cellular degradation pathways. To address these therapeutic needs, this proposal aims to develop a responsive gene therapy for the self-sufficient delivery of neuroprotective therapies targeting the clearance of misfolded α-syn species. In a cellular model of α-syn seeded aggregation, we will demonstrate that our gene therapy approach can detect biological responses associated with the accumulation of α-syn and respond by modulating protein degradation pathways accordingly. We expect the outcomes of this project to enable a strategy where a therapy is produced as needed by the affected brain regions, opening the possibility to intervene at an early stage for the treatment of otherwise intractable neurodegenerative conditions such as PD. 

 

 

 

Additional Information

In Campus Calendar
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Graduate Studies

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Public, Graduate students, Undergraduate students
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Other/Miscellaneous
Keywords
Phd Defense
Status
  • Created By: Tatianna Richardson
  • Workflow Status: Published
  • Created On: Sep 24, 2018 - 11:36am
  • Last Updated: Sep 24, 2018 - 11:37am