Trailblazing Molecular Jungles with New Nuclear Magnetic Resonance Consortium

Emory University, Georgia State University and Georgia Tech team up to optimize use of NMR spectrometry

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Media relations contact: Maureen Rouhi, maureen.rouhi@cos.gatech.edu

Writers: Ben Brumfield / Maureen Rouhi

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Nature is chock full of chemical labyrinths that NMR helps navigate, but the technology is pricey, so teaming up to optimize use and share costs makes great sense.

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What do crab urine, human lymph samples, and eons-old rock records have in common? Hundreds, thousands or more kinds of molecules make them up, so many a postdoc or graduate researcher have pulled their hair out trying to isolate one or two compounds. NMR is so much faster and more efficient, but it can be pricey, so Atlanta area universities have partnered up to optimize use and costs, and to offer use to outside researchers.

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  • Julia Kubanek NMR with Serge Lavoie Julia Kubanek NMR with Serge Lavoie
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  • Leslie Gelbaum and Johannes Leisen during unpacking of new NMR instruments in July 2016. Photo by Julia Kubanek. Leslie Gelbaum and Johannes Leisen during unpacking of new NMR instruments in July 2016. Photo by Julia Kubanek.
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  • Bruker AVIII-400 Bruker AVIII-400
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  • Atlanta NMR Consortium Atlanta NMR Consortium
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They may look a little like space capsules, but nuclear magnetic resonance spectrometers stay planted on the floor and use potent magnetism to explore opaque constellations of molecules.

Three Atlanta area universities jointly launched a nuclear magnetic resonance collaboration called the Atlanta NMR Consortium to optimize the use of this technology that provides insights into relevant chemical samples containing so many compounds that they can otherwise easily elude adequate characterization. The consortium has been operating since July 2018.

Crab pee

Take, for example, crab urine. It’s packed with hundreds to thousands of varying metabolites, and researchers at the Georgia Institute of Technology wanted to nail down one or two of them that triggered a widespread crab behavior. Without access to NMR they may not have found them at all even after an extensive search.

The spectrometer pulled the right two needles out of the haystack, so the researchers could test them on the crabs and confirm that they were initiating the behavior.

Emory University, Georgia State University and Georgia Tech already have NMR technology, but the Atlanta NMR Consortium will enable them to fully exploit it while cost-effectively staying on top of upgrades.

“NMR continues to grow and develop because of technological advances,” said David Lynn, a chemistry professor at Emory University.

That means buying new machines every so often, and one new NMR spectrometer can run into the millions; annual maintenance for one machine can cost tens of thousands of dollars. Thus, reducing costs and maximizing usage makes good sense.

Medicine, geochemistry

The human body, sea-side estuaries, and rock strata present huge collections of compounds. NMR takes inventory of complex samples from such sources via the nuclei of atoms in the molecules.

A nucleus has a spin, which makes it magnetic, and NMR spectrometry’s own powerful magnetism detects spins and pinpoints nuclei to feel out whole molecules. These can be large or small, from mineral compounds with three or four component atoms to protein polymers with tens of thousands of parts.

Researchers in medicine, biochemistry, ecology, geology, food science – the possible list is exhaustive -- turn to NMR to untangle their particular molecular jungles. The consortium wants to leverage that diversity.

“As we go in different directions, we will benefit from a cohesive community of people who know how to use NMR for a wide range of problems,” said Anant Paravastu, an associate professor in Georgia Tech’s School of Chemical and Biomolecular Engineering.

“The most important goal for us is the sharing of our expertise,” said Markus Germann, a professor of chemistry at Georgia State.

Consortium members will benefit the most from the pooled NMR resources, but non-partners can also book access. Read more about the Atlanta NMR Consortium here on Georgia Tech’s College of Sciences website

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Keywords
Emory University, Georgia State University, nuclear magnetic resonance spectrometers, metabolites, nucleus spin, proton spin
Status
  • Created By: Ben Brumfield
  • Workflow Status: Published
  • Created On: Sep 11, 2018 - 10:48am
  • Last Updated: Sep 11, 2018 - 12:24pm