Integrated Cancer Research Center Seminar Series

Event Details
  • Date/Time:
    • Tuesday September 18, 2018
      4:00 pm - 5:00 pm
  • Location: Petit Biotechnology Building, Room 1128 - Atlanta, GA
  • Phone:
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

John McDonald - faculty host

Summaries

Summary Sentence: "Selectively Killing Cancers Through Catalytically Destroying their Anti-Oxidative Defenses" - Jie Song, Ph.D. - Emory University

Full Summary: No summary paragraph submitted.

"Selectively Killing Cancers Through Catalytically Destroying their Anti-Oxidative Defenses"

Jie Song, Ph.D.
Faculty Fellow

Department of Chemistry
Emory University 

Cancer remains a leading killer: 14 million new cases and 8.2 million cancer deaths worldwide were recorded in the year 2012 while the incidence and mortality are estimated to rise to 21 million and 13 million by 2030, respectively (Cancer Statistics, NCI website). The fact that cancer variants have evolved into new and intractable types or subtypes, which exhibit inherent or acquired resistance to current clinically-used chemotherapeutics, imposes a challenge in cancer treatments. Extensive efforts have been devoted to the development of new anti-cancer agents including both chemical, immunological, and biologic therapeutics, however, the success rate remains very low. Developing new anti-cancer therapeutics, ideally with novel mechanisms of action is extremely challenging. In this talk, I will present our recent discovery that a nanoscale zwitterionic molecule, VPOA-6, exhibits remarkable selectivity in killing cancer cells while sparing normal cells in vitro. Our in vivo data demonstrate this agent markedly inhibits human tumor growth in mouse models. Mechanistic studies reveal that VPOA-6 dramatically alters the cancer redox balance by devastating its antioxidative capacity, leading to a ROS surge and cell apoptosis. These data further lead us to determine the relationship between the structural and other properties of VPOA-6 and its cancer-killing effect as well as its efficacy in tumor inhibition.

Related Links

Additional Information

In Campus Calendar
Yes
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Faculty/Staff, Public, Undergraduate students
Categories
Seminar/Lecture/Colloquium
Keywords
go-PetitInstitute, go-icrc-events, go-icrc
Status
  • Created By: Floyd Wood
  • Workflow Status: Published
  • Created On: Aug 20, 2018 - 11:27am
  • Last Updated: Aug 20, 2018 - 11:47am