BioE PhD Defense Presentation- Albert Cheng

Event Details
  • Date/Time:
    • Tuesday March 27, 2018
      2:00 pm - 4:00 pm
  • Location: CHOA Room EBB
  • Phone:
  • URL:
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  • Fee(s):
    N/A
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Contact

Laura Paige

404-385-6655

Summaries

Summary Sentence: "Patient-specific Approaches to Bone Regeneration"

Full Summary: BioE PhD Defense Presentation- "Patient-specific Approaches to Bone Regeneration"- Albert Cheng

Advisor: Robert E. Guldberg, Ph.D. (Georgia Institute of Technology)

 

Committee:

Johnna S. Temenoff, Ph.D. (Georgia Institute of Technology)

Krishnendu Roy, Ph.D. (Georgia Institute of Technology)

Greg Gibson, Ph.D. (Georgia Institute of Technology)

Steven L. Stice, Ph.D. (University of Georgia)

 

 

Patient-specific Approaches to Bone Regeneration

 

Bone is the second-most transplanted tissue after blood with more than 1.6 million bone grafting procedures performed annually in the US at a cost of over 5 billion dollars. Treatment of large bone defects in particular remains one of the most challenging problems faced by orthopedic surgeons. Current therapies include bone grafts and/or delivery of osteoinductive proteins such as bone morphogenetic protein 2 (BMP-2). Despite advances in surgical technique and medical care, many of these treatment options still exhibit high variability in healing, suggesting that patient-specific factors, such as age, gender, treatment timing, and immune status, may play a much more crucial role in treatment success than previously thought. Thus, the need to account for these patient-specific factors with more sophisticated treatment strategies has become increasingly apparent.

 

            The main objective of this work was to use preclinical animal models to investigate the influence of patient-specific factors on bone regeneration, with a particular focus on long-term immune profile characterization as it relates to the bone healing response after treatment. The impact of age and dose on large bone defect healing was assessed using a well-established bone injury rat model along with delivery of BMP-2 in a collagen sponge, which is the current clinical standard. These results offer valuable insight on a controversial subject: the use of BMP-2 in pediatric patients. Additionally, this work sought to elucidate some of the key mechanisms that lead to impaired healing following nonunion, a significant clinical problem that still affects up to 10% of patients with long bone injuries. To accomplish this, a chronic nonunion model was established that can potentially serve as a more rigorous and clinically relevant platform for studying nonunion and testing novel therapeutics. Finally, the issue of trauma-induced immune dysregulation was evaluated in this model of nonunion as a potential harbinger of poor healing outcome. Collectively, these studies have advanced our understanding of the factors that affect bone regeneration and represent a pivotal step towards improved, more personalized treatment strategies for bone repair.

 

 

Additional Information

In Campus Calendar
No
Groups

Bioengineering Graduate Program

Invited Audience
Faculty/Staff, Public, Undergraduate students
Categories
Career/Professional development
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Status
  • Created By: Laura Paige
  • Workflow Status: Published
  • Created On: Mar 13, 2018 - 10:45am
  • Last Updated: Mar 13, 2018 - 10:45am