GT Neuro Seminar Series

Event Details
  • Date/Time:
    • Monday March 12, 2018
      11:15 am - 12:15 pm
  • Location: Krone Engineered Biosystems Building, Room 1005 - Atlanta, GA
  • Phone:
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

Chris Rozell - faculty host

Summaries

Summary Sentence: “Effects of Nicotine on Brain and Behavior: How nAChRs Modulate Circuits Related to Mood and Aggression” - Marina Picciotto, Ph.D. - Yale University

Full Summary: No summary paragraph submitted.

“Effects of Nicotine on Brain and Behavior: How nAChRs Modulate Circuits Related to Mood and Aggression”  

Marina Picciotto, Ph.D.
Charles B.G. Murphy Professor
Department of Psychiatry
Yale University

Acetylcholine signaling influences behaviors related to diverse functions, including drug abuse, attention, food intake, and mood. The ability of acetylcholine to coordinate the response of neuronal networks in many brain areas makes cholinergic modulation an essential mechanism underlying complex behaviors. Interestingly, increasing acetylcholine signaling using pharmacological or genetic methods can induce symptoms related to anxiety and depression in humans and in rodent models. Studies of anxiety- and depression-like behaviors in mice have identified specific cholinergic receptors and brain areas that are necessary for ACh effects. In addition, mouse studies have identified interactions between ACh and monoamine neurotransmitters that are targeted by most antidepressant medications that are effective in human patients. These studies suggest that abnormalities in the cholinergic system may be critical for the etiology of mood disorders and could represent a novel endophenotype of depression that could be targeted to develop novel antidepressant medications. Thus, ACh signaling could contribute to the balance between adaptive responses to stress and mood disorders.

This presentation can be seen via videoconference on the Emory Campus HSRB E260

Related Links

Additional Information

In Campus Calendar
Yes
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Faculty/Staff, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
go-PetitInstitute, go-neuro, gtneuro
Status
  • Created By: Floyd Wood
  • Workflow Status: Published
  • Created On: Mar 1, 2018 - 12:41pm
  • Last Updated: Mar 1, 2018 - 12:41pm