In January 1952, Ernesto (played by Gael García Bernal) is a 23-year-old medical student specializing in leprology. Alberto (Rodrigo de la Serna), age 29, is a biochemist. The two men bid goodbye to their families and to Ernesto's girlfriend Chichina Ferreyra (Mía Maestro). Flushed with a romantic sense of adventure, they pile onto Alberto's 1939 Norton 500 motorcycle (nicknamed "La Poderosa" ["The Mighty One"]). The aging bike carries them farther and farther away from familiar and comfortable Buenos Aires surroundings, to surprising and exciting destinations. The two friends become as close as brothers. Over the course of eight months and 8,000 miles, what starts out as a lark becomes a profound journey of discovery, not only of themselves but of a continent filled with infinite sorrow, and infinite hope. From homeless miners to riverboat prostitutes, from lepers to prosperous gentry, Ernesto and Alberto discover an affinity for humanity within themselves, and a determination to change the world.

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