BME-PKU Defense: Jinyang Wang

Date: Wednesday, June 7th (Atlanta) / Thursday, June 8th (Beijing)

Time: 8:15 PM (Atlanta) / 8:15 AM (Beijing)

Location: Video conference (Atlanta, see below for connection info*) / Integrated science building  room 425

Committee Members:

Ying Luo, PhD (Advisor, PKU-BME)

W. Robert Taylor, MD, PhD (Co-advisor, GT-BME)

Huaiqiu Zhu, PhD (PKU-BME)

Changhui Li, PhD (PKU-BME)

Xiumei Wang, PhD (Tsinghua university)

Title:

Scaffold with integrated properties and applications in cell transplantation

Abstract:

Tissue scaffolds are gaining increasing importance in cell therapy applications, where they serve as cell carriers to overcome the low cell retention and survival caused by direct injection of cells. Cell response (from both therapeutic cells and host tissue) is dependent on multiple properties (chemistry, mechanical property and topology) of scaffolds. To achieve improved in vivo performance, optimization on multiple properties of scaffolds are desired. However, traditional scaffolds are often composed of single material with distinct merits as well as drawbacks and usually display bulk topology, lacking regulation of cells on multiple scales.

In this project, three types of scaffolds with integrated properties were developed and characterized. In the first study, nano-thin hydrogel was integrated on surface of polyester microfiber. After integration, the scaffold became water absorbable meanwhile preserving the mechanical strength of microfibers. In the second study, scaffolds with multiple scales of topologies was achieved by introducing microwell patterns on electrospun fibers. We found the microwell patterns could regulate the spatial distribution of seeded mesenchymal stem cell (MSC) spheroids. We further tested their application in MSC transplantation in mice model of hind limb ischemia. In the third study, spherical hollow scaffolds with controllable pore size were developed. The scaffold showed unique parallel channels bearing nanoscale to microscale pores. When loaded with MSCs, the cells showed in vitro cellular responses and in vivo residence time that were correlatable with the pore structures within the bead wall. Overall, this work adds to our knowledge of strategies for development of scaffold with integrated properties, and broadens our understanding of design principles of scaffolds to be used for cell transplantation.

To join the Meeting:

https://bluejeans.com/681178207

To join via phone :

1)  Dial:

                +1.408.740.7256 (United States)

                +1.888.240.2560 (US Toll Free)

                +1.408.317.9253 (Alternate number)

                (see all numbers - http://bluejeans.com/numbers)

2)  Enter Conference ID : 681178207