2017 VWR Seminar: Building Chromatin: Assembly and Evolution of Nucleosomes

Event Details
  • Date/Time:
    • Thursday March 16, 2017
      11:00 am - 12:00 pm
  • Location: Georgia Tech, EBB 1005
  • Phone: 404-894-3700
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact
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Summaries

Summary Sentence: Karolin Luger, University of Colorado

Full Summary: Karolin Luger
HHMI Investigator
Jennie-Smoly-Caruthers Endowed Chair of Chemistry and Biochemistry
University of Colorado
Abrstact: Nucleosome assembly in the wake of DNA replication is a key process that regulates cell identity and survival. Chromatin assembly factor 1 (CAF-1) is a H3-H4 histone chaperone that associates with the replisome and orchestrates chromatin assembly following DNA synthesis. Little is known about the mechanism and structure of this key complex. We investigate CAF-1 – histone binding modes and describe an intriguing ‘snap-on’ mechanism by which CAF-1 assembles nucleosomes. In contrast to eukaryotes, many archaea have histone-based chromatin that does not require assembly factors. I will present the structure of archaeal chromatin, and discuss possible implications for the origins of the eukaryotic nucleosome.   A lunch reception will follow the seminar in EBB 5029 at 12 PM.

Karolin Luger
HHMI Investigator
Jennie-Smoly-Caruthers Endowed Chair of Chemistry and Biochemistry
University of Colorado

Abrstact:

Nucleosome assembly in the wake of DNA replication is a key process that regulates cell identity and survival. Chromatin assembly factor 1 (CAF-1) is a H3-H4 histone chaperone that associates with the replisome and orchestrates chromatin assembly following DNA synthesis. Little is known about the mechanism and structure of this key complex. We investigate CAF-1 – histone binding modes and describe an intriguing ‘snap-on’ mechanism by which CAF-1 assembles nucleosomes.

In contrast to eukaryotes, many archaea have histone-based chromatin that does not require assembly factors. I will present the structure of archaeal chromatin, and discuss possible implications for the origins of the eukaryotic nucleosome.

 

A lunch reception will follow the seminar in EBB 5029 at 12 PM.

Additional Information

In Campus Calendar
Yes
Groups

School of Biological Sciences, College of Sciences

Invited Audience
Faculty/Staff, Public, Undergraduate students, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
School of Biological Sciences Seminar, Yuhong Fan, Karolin Luger
Status
  • Created By: Jasmine Martin
  • Workflow Status: Published
  • Created On: Feb 16, 2017 - 2:25pm
  • Last Updated: Apr 13, 2017 - 5:12pm