Tony Capra, Vanderbilt University

Event Details
  • Date/Time:
    • Wednesday February 8, 2017
      3:00 pm - 4:00 pm
  • Location: Georgia Tech, Marcus 1117-1118
  • Phone: 404-894-3700
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
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Summaries

Summary Sentence: The Phenotypic Legacy of Neanderthal Interbreeding on Modern Humans

Full Summary: The Phenotypic Legacy of Neanderthal Interbreeding on Modern Humans
Abstract:

Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such as Neanderthals, yet the influence of this admixture on human traits is largely unknown. We analyzed the contribution of common Neanderthal variants to over 1000 electronic health record (EHR)–derived phenotypes in ~28,000 adults of European ancestry. We discovered and replicated associations of Neanderthal alleles with neurological, psychiatric, immunological, and dermatological phenotypes. Neanderthal alleles together explained a small, but significant fraction of the variation in risk for depression and skin lesions resulting from sun exposure (actinic keratosis), and individual Neanderthal alleles were associated with specific human phenotypes, including hypercoagulation and tobacco use. Our results establish that archaic admixture influences disease risk in modern humans, provide hypotheses about the effects of hundreds of Neanderthal haplotypes, and demonstrate the utility of EHR data in evolutionary analyses.

The Phenotypic Legacy of Neanderthal Interbreeding on Modern Humans
Abstract:

Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such as Neanderthals, yet the influence of this admixture on human traits is largely unknown. We analyzed the contribution of common Neanderthal variants to over 1000 electronic health record (EHR)–derived phenotypes in ~28,000 adults of European ancestry. We discovered and replicated associations of Neanderthal alleles with neurological, psychiatric, immunological, and dermatological phenotypes. Neanderthal alleles together explained a small, but significant fraction of the variation in risk for depression and skin lesions resulting from sun exposure (actinic keratosis), and individual Neanderthal alleles were associated with specific human phenotypes, including hypercoagulation and tobacco use. Our results establish that archaic admixture influences disease risk in modern humans, provide hypotheses about the effects of hundreds of Neanderthal haplotypes, and demonstrate the utility of EHR data in evolutionary analyses.

Additional Information

In Campus Calendar
Yes
Groups

School of Biological Sciences

Invited Audience
Faculty/Staff, Public, Undergraduate students, Graduate students
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Keywords
School of Biological Sciences Seminar, Joe Lachance, Tony Capra
Status
  • Created By: Jasmine Martin
  • Workflow Status: Published
  • Created On: Jan 6, 2017 - 12:03pm
  • Last Updated: Apr 13, 2017 - 5:13pm