PhD Proposal by Joshua Hooks

Event Details
  • Date/Time:
    • Friday September 9, 2016
      1:00 pm - 3:00 pm
  • Location: EBB Children's Health Care of Atlanta Seminar Room(1005)
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Summaries

Summary Sentence: Role of Mechanical Microenvironment on the Regulation of Lymphatic Function and Health

Full Summary: No summary paragraph submitted.

Joshua Hooks

PhD Proposal Presentation 

 

Date: Friday, September 9, 2016

Time: 1:00pm

Location: EBB Children's Health Care of Atlanta Seminar Room(1005)

 

Advisor: 

J. Brandon Dixon, Ph.D. (ME/Georgia Institute of Technology)

 

Committee:

Andrés J. García, Ph.D. (ME/Georgia Institute of Technology)

C. Ross Ethier, Ph.D. (BME/(Georgia Institute of Technology)

Michael Davis, Ph.D. (BME/Georgia Institute of Technology & Emory University)

Mariappan Muthuchamy, Ph.D. (Medical Physiology/Texas A&M)

 

 

Role of Mechanical Microenvironment on the Regulation of Lymphatic Function and Health

 

Failure of lymph fluid transport plays an important role in pathologies, such as lymphedema and lymphacele after organ donation. The lymphatic system plays a critical role in maintaining fluid homeostasis in all of the soft tissue of the body. Its ability to transport interstitial fluid is partially dependent on the intrinsic pumping capacity of lymphatic smooth muscle cells. Recently, our lab has shown that lymphatic collecting vessels near an injury never return to pre-injury levels of pumping and lymph transport, but factors that impact collecting vessel phenotype are poorly understood. The central hypothesis of this work is that the components of the extracellular matrix (ECM) and mechanics of the lymphatic microenvironment play a central role in the contractile phenotype of lymphatic muscle cells (LMCs). 

 

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Phd proposal
Status
  • Created By: Tatianna Richardson
  • Workflow Status: Published
  • Created On: Aug 26, 2016 - 4:36am
  • Last Updated: Oct 7, 2016 - 10:18pm