Peter B. Sherry Memorial Lecture

Event Details
  • Date/Time:
    • Thursday March 31, 2016
      4:00 pm - 5:00 pm
  • Location: Molecular Science and Engineering Building, 901 Atlantic Dr Atlanta, GA 30332, Room G011
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  • Fee(s):
    N/A
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Contact
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Summaries

Summary Sentence: Caltech Professor Harry Gray will give a lecture on "The Currents of Life: Electron Flow Through Proteins."

Full Summary: No summary paragraph submitted.

Media
  • Harry Gray Poster Harry Gray Poster
    (image/png)

The Currents of Life: Electron Flow through Proteins

Biological electron transfers often occur between metal-containing cofactors that are separated by very large molecular distances. Understanding the underlying physics and chemistry of these long-range electron transfer processes is the goal of much of the work in my laboratory.

Employing laser flash-quench triggering methods, my coworkers and I have shown that 2-nm, coupling-limited Fe(II) to Ru(III) and Cu(I) to Ru(III) electron tunneling reactions in Ru-modified cytochromes and blue copper proteins occur on microsecond to nanosecond timescales. We also have demonstrated that redox equivalents can be transferred even longer distances by multistep tunneling (hopping) through intervening tyrosines and tryptophans: notably, in work on cytochrome P450 and azurin, we have found that long-range hole hopping through intervening tryptophans can be orders of magnitude faster than single-step tunneling.

Could hole hopping through Tyr/Trp chains protect redox enzymes from oxidative damage? We think so! By examining the structures of P450 and related enzymes, we have identified candidate Tyr/Trp chains that could transfer holes from uncoupled high-potential intermediates to cellular reductants in contact with protein surface sites.

Additional Information

In Campus Calendar
Yes
Groups

College of Sciences

Invited Audience
Undergraduate students, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
electron flow, oxidative damage, proteins
Status
  • Created By: A. Maureen Rouhi
  • Workflow Status: Published
  • Created On: Mar 30, 2016 - 7:37am
  • Last Updated: Apr 13, 2017 - 5:16pm