Pedro Beltrao, European Molecular Biology Laboratory at the European Bioinformatics Institute

Event Details
  • Date/Time:
    • Thursday October 29, 2015
      11:00 am
  • Location: Georgia Tech, Klaus Advanced Computing Building, 1116W
  • Phone: (404) 894-3700
  • URL:
  • Email: bio-admin@biology.gatech.edu
  • Fee(s):
    N/A
  • Extras:
Contact

If you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biology's administrative office at bio-admin@biology.gatech.edu.

Summaries

Summary Sentence: Pedro Beltrao, European Molecular Biology Laboratory at the European Bioinformatics Institute

Full Summary: Abstract:Cells need to constantly adapt to changes in conditions and use different mechanisms to transfer information from sensors to the effectors of cellular responses. One of the fastest mechanisms is the reversible post-translational modification of proteins such as protein phosphorylation. Advances in mass-spectrometry now allow us to identify phosphosites in large scale and quantify their changes across different conditions. However, little is know about how the thousands of recently discovered phosphosites evolve, how they modulate protein function or how they act in coordinate fashion to dictate a cellular response. I will describe recent progress from our group in addressing these issues. We are developing methods to infer the most likely age of phosphosites by combining phosphorylation data from multiple species, protein sequences and phylogenetic trees. We have observed that only a small fraction of phosphosites are ancient in origin and that these are more likely to cause deleterious consequences when mutated. In parallel we are analysing changes in phosphosite abundances under different conditions. We have compiled a dataset of 150 perturbations in human cell lines where we can estimate the activities of approximately 200 kinases. These data allows to characterize cell signalling states across conditions and to infer associations between kinase activities and the phosphorylation levels of protein complexes.

Evolution and Function of Protein Phosphorylation Networks

Additional Information

In Campus Calendar
No
Groups

School of Biological Sciences

Invited Audience
Undergraduate students, Faculty/Staff, Public, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
Matthew Torres, Pedro Beltrao, School of Biology
Status
  • Created By: Jasmine Martin
  • Workflow Status: Published
  • Created On: Jul 30, 2015 - 7:57am
  • Last Updated: Apr 13, 2017 - 5:18pm