Familial aggregation of multivariate traits: testing & var. selection

Event Details
  • Date/Time:
    • Thursday February 26, 2009
      10:00 am - 11:00 am
  • Location: Executive classroom
  • Phone:
  • URL:
  • Email:
  • Fee(s):
    $0.00
  • Extras:
Contact
Nicoleta Serban
ISyE
Contact Nicoleta Serban
404-385-7255
Summaries

Summary Sentence: Familial aggregation of multivariate traits: testing & var. selection

Full Summary: Familial aggregation of multivariate traits: testing and variable selection

TITLE: Familial aggregation of multivariate traits: testing and variable selection

SPEAKER: Professor Yixin Fang

ABSTRACT:

In genetic epidemiology, the first and foremost task is testing for familial aggregation; if no familial aggregation is found, it is unnecessary to conduct further genetic analysis. For multivariate traits, we propose a test statistic, which is actually the leading principal component of heritability. The p-value can be obtained by a permutation procedure or a theorem of Johnstone and Forrester (2004). Furthermore, if the test is significant, it is desired to get rid of those redundant traits to avoid overfitting. To this aim, a cross-validation approach and its approximation are proposed. The talk concludes with some discussion on testing for familial aggregation of functional traits and an application to the cholesterol data from Framingham Heart Study.

Additional Information

In Campus Calendar
No
Groups

H. Milton Stewart School of Industrial and Systems Engineering (ISYE)

Invited Audience
No audiences were selected.
Categories
Seminar/Lecture/Colloquium
Keywords
familial aggregation
Status
  • Created By: Anita Race
  • Workflow Status: Published
  • Created On: Oct 12, 2009 - 4:36pm
  • Last Updated: Oct 7, 2016 - 9:47pm