Chemical Biology Seminar

Event Details
  • Date/Time:
    • Monday September 15, 2014
      11:00 am - 12:00 pm
  • Location: MoSE 3201A
  • Phone:
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

MG Finn, PhD

Summaries

Summary Sentence: "Cu, Zn Superoxide Dismutase and ALS: To Charge or Not to Charge?" - Bryan Shaw, PhD - Baylor University

Full Summary: Chemical Biology Seminar - "Cu, Zn Superoxide Dismutase and ALS: To Charge or Not to Charge?" - Bryan Shaw, PhD - Baylor University

"Cu, Zn Superoxide Dismutase and ALS: To Charge or Not to Charge?"

Bryan Shaw, PhD
Baylor University

Historically, small molecule drugs have been designed to permute the function of a protein by targeting parameters such as Km, Vmax, Kd, or ∆Gf‡. One parameter—a protein’s net electrostatic charge (Z)—has been categorically overlooked as a medicinal “target”. Can we design drugs to target a protein’s net charge, for example a drug that boosts the net charge of a protein in order to inhibit its amyloidogenesis and cellular permeability? This talk will discuss the rationale and initial testing of this “charge boosting” hypothesis within the context of amyotrophic lateral sclerosis (ALS) that is caused by the self-assembly of Cu, Zn superoxide dismutase (SOD1). At the end of the presentation, a new hypothesis on the chemical etiology of sporadic ALS will also be presented (see Shi, Y., et al., J. Am. Chem. Soc. 2013; 135(42):15897-908).

Related Links

Additional Information

In Campus Calendar
Yes
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
No keywords were submitted.
Status
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Sep 4, 2014 - 8:26am
  • Last Updated: Apr 13, 2017 - 5:21pm