Integrated Cancer Research Center Seminar

Event Details
  • Date/Time:
    • Tuesday September 23, 2014
      4:00 pm - 5:00 pm
  • Location: Parker H. Petit Institute for Bioengineering & Bioscience, Room 1128
  • Phone: (404) 894-6228
  • URL: http://www.ibb.gatech.edu
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

John McDonald, PhD

Summaries

Summary Sentence: "Protease Signatures in Cancer Diagnostics" - Stefan H. Bossmann, PhD - Kansas State University

Full Summary: Georgia Tech has been a leader in the development of collaborative approaches to both cancer diagnostics and therapeutics. The mission of the Integrated Cancer Research Center (ICRC) is to facilitate integration of the diversity of technological, computational, scientific and medical expertise at Georgia Tech and partner institutions in a coordinated effort to develop improved cancer diagnostics and therapeutics.

"Protease Signatures in Cancer Diagnostics"

Stefan H. Bossmann, PhD
Professor, Department of Chemistry

Terry C. Johnson Cancer Center
The Midwestern Institute for Comparative Stem Cell Biology
Kansas State University
The University of Kansas Cancer Center
Honorary Distinguished Professor, Kunming University, Kunming, China

Numerous proteases are involved in cancer development and progression including Matrix Metalloproteinases (MMPs), Tissue Serine Proteases, and Cathepsins. We have designed nanoplatforms consisting of fluorescent dyes that are attached to Fe/Fe3O4 nanoparticles via consensus sequences. Their detection limits when using fluorescence plate reader technology are in the sub-femtomolar range. Based on the expression pattern of up to 20 proteases, we were able to:

  • Detect early lung and breast cancers (stage 1) in blood serum. 
  • Discern sub-groups in Triple Negative Cancer
  • Characterize tissue samples from mastectomies
  • Observe post-operative effects in protease expression pattern

Based on our recent findings, there is emerging evidence that different cancers feature various "protease signatures," meaning that the levels of protease over-expression will differ, depending on the origin and stage of cancer. This permits the diagnosis of various solid tumors at their specific stages.

 

Related Links

Additional Information

In Campus Calendar
Yes
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
IBB, ICRC Seminar
Status
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Aug 26, 2014 - 5:42am
  • Last Updated: Apr 13, 2017 - 5:21pm