Center for Immunoengineering Seminar

Event Details
  • Date/Time:
    • Thursday May 29, 2014
      3:00 pm - 4:00 pm
  • Location: Parker H. Petit Institute for Bioengineering & Bioscience, Room 1128
  • Phone: (404) 894-6228
  • URL: http://www.ibb.gatech.edu
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

Melissa Kemp, PhD - faculty host

Summaries

Summary Sentence: "Viral Gene Circuits: Simple Model Systems and a New Spectrum of Antiviral Targets" - Leor S. Weinberger, PhD - University of California, San Francisco

Full Summary: "Viral Gene Circuits: Simple Model Systems and a New Spectrum of Antiviral Targets" - Leor W. Weinberger, PhD - Gladstone Institutes, University of California, San Francisco

"Viral Gene Circuits: Simple Model Systems and a New Spectrum of Antiviral Targets"

Leor S. Weinberger, PhD
Associate Investigator 
Gladstone Institute of Virology and Immunology
Associate Professor of Biochemistry & Biophysics 
University of California, San Francisco


Viral gene circuits are bounded by many of the same design constraints as electrical circuits (e.g., signal-to-noise ratio) but rapidly mutating viruses, like HIV, evolved unique mechanisms to circumvent these circuitry barriers.  These adaptations are essential to the evolutionary fitness of viruses and offer targets for novel antiviral therapies.  I will describe two viral circuit adaptations, the first in HIV (Weinberger & Weinberger, Cell, 2013) and the second in the human herpesvirus CMV (Teng et al., Cell, 2012), the leading cause of birth defects and transplant rejections.  I will also discuss very recent work on disrupting and exploiting these circuit architectures for new therapies (Dar et al. Science, in press).

 

Related Links

Additional Information

In Campus Calendar
Yes
Groups

Wallace H. Coulter Dept. of Biomedical Engineering, Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
IBB
Status
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: May 21, 2014 - 7:59am
  • Last Updated: Apr 13, 2017 - 5:22pm