Petit Institute Seminar

Event Details
  • Date/Time:
    • Tuesday April 29, 2014
      11:00 am - 12:00 pm
  • Location: Parker H. Petit Institute for Bioengineering & Bioscience, Room 1128
  • Phone: (404) 894-6228
  • URL: http://www.ibb.gatech.edu
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

Cheng Zhu, PhD - faculty host

Summaries

Summary Sentence: "Exploring T Cell Activation and Differentiation by MS-based Proteomics" - Oreste Acuto, PhD - University of Oxford

Full Summary: The Petit Institute hosts special guests and visitors throughout the year.  These seminars are open to all faculty and students.

Media
  • Parker H. Petit Institute for Bioengineering and Bioscience Parker H. Petit Institute for Bioengineering and Bioscience
    (image/jpeg)
  • Oreste Acuto, PhD - University of Oxford Oreste Acuto, PhD - University of Oxford
    (image/jpeg)

"Exploring T Cell Activation and Differentiation by MS-based Proteomics"

Oreste Acuto, PhD

Professor and Senior Research Fellow
Sir William Dunn School of Pathology
University of Oxford

Recent progress in advanced quantitative mass spectrometry allows investigation of cellular proteomes at unprecedented levels of deepness and information abundance, comparable, if not superior to transcriptome analyses.
These advances permit now the use of limited amounts of biological material, not only to identify predictable missing links and unexpected connection in cellular pathways at the protein and metabolic levels, but also to appreciate changing patterns in cellular functions associated with cell differentiation at systems level.

During the last few years we have widely applied MS-based proteomics to T cell activation and differentiation, a biology and bio-medical research relevant system to understand complex processes set in motion by T cell antigen receptor (TCR) stimulation, in normal and pathological settings.

I will discuss recent data on the MS-based discovery and functional characterization of Themis, a novel protein implicated in thymus development of conventional T cells. Moreover, I will illustrate various approaches that have allowed reveal global changes protein phosphorylation and/or protein expression patterns upon TCR stimulation. Finally, I will report unpublished data on extensive cellular "methylome" studies in T differentiating cells.

Faculty host - Cheng Zhu, PhD

Related Links

Additional Information

In Campus Calendar
Yes
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Bioengineering Graduate Program

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
IBB, IBB Seminar
Status
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Feb 6, 2014 - 4:49am
  • Last Updated: Apr 13, 2017 - 5:23pm