John McDonald, Georgia Institute of Technology

Event Details
  • Date/Time:
    • Thursday February 6, 2014
      10:00 am - 11:00 am
  • Location: Klaus 1116E
  • Phone: (404) 894-3700
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

If you have questions about logistics or would like to set up an appointment with a speaker, please contact please contact the School of Biology's Administrative office at bio-admin@biology.gatech.edu.

Summaries

Summary Sentence: Title: Genomic analysis of ovarian cancer metastasis: towards improved understanding and treatment

Full Summary: Title: Genomic analysis of ovarian cancer metastasis: towards improved understanding and treatment 

Title: Genomic analysis of ovarian cancer metastasis: towards improved understanding and treatment

Abstract:
It is widely acknowledged that the metastatic spread of cancer cells is responsible for most cancer related deaths. This is particularly true for ovarian cancer (OC) where the prospect of favorable outcome drops precipitously once cancer cells migrate beyond the confines of the primary tumor. Our laboratory is interested in using genomic approaches to better understand the molecular processes underlying OC metastasis and to develop novel therapeutic strategies to inhibit metastasis and improve patient outcome.  Preliminary evidence suggests that OC metastases can be established from low frequency sub-clones present within the primary tumor resulting in significant genetic divergence between primary and metastatic tumors.  Additional evidence indicates that the OC metastatic process involves epithelial-to-mesenchymal transition (EMT) with a concomitant reduction in the sensitivity of metastasizing cells to standard (platinum-based) chemotherapies. Ectopic over-expression of members of the miR-200 family of microRNAs is emerging as an effective strategy to reverse EMT and increase the sensitivity of metastatic OC cells to standard chemotherapies.

Additional Information

In Campus Calendar
No
Groups

School of Biological Sciences

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
John McDonald, School of Biology Seminar
Status
  • Created By: Jasmine Martin
  • Workflow Status: Published
  • Created On: Jan 27, 2014 - 5:47am
  • Last Updated: Apr 13, 2017 - 5:23pm