Integrated Cancer Research Center Seminar Series

Event Details
  • Date/Time:
    • Tuesday March 25, 2014
      4:00 pm - 5:00 pm
  • Location: Parker H. Petit Institute for Bioengineering & Bioscience, Room 1128
  • Phone: (404) 894-6228
  • URL: http://www.ibb.gatech.edu
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

John McDonald, PhD

Summaries

Summary Sentence: "Regulating Energy and Lipid Metabolism through Pluripotent Transcriptional Networks" - Martin J. Walsh, PhD, Mt. Sinai School of Medicine

Full Summary: Georgia Tech has been a leader in the development of collaborative approaches to both cancer diagnostics and therapeutics. The mission of the Integrated Cancer Research Center (ICRC) is to facilitate integration of the diversity of technological, computational, scientific and medical expertise at Georgia Tech and partner institutions in a coordinated effort to develop improved cancer diagnostics and therapeutics.

"Regulating Energy and Lipid Metabolism through Pluripotent Transcriptional Networks"

Martin J. Walsh, PhD

Associate Professor, Structural and Chemical Biology
Associate Professor, Pediatrics, Hepatology
Associate Professor, Genetics and Genomic Sciences
Mt. Sinai School of Medicine

Glycolysis and lipid biosynthesis are crucial to stem cell behavior, but we know little about the transcriptional regulation of factors driving metabolism in concert with stem cell fate. We demonstrate through use of selective BET-bromodomain inhibitors, and comprehensive RNA-seq and ChIP-seq analysis in mouse embryonic stem cells (ESCs), that Brd4, a master chromatin reader, governs transcription of the core pluripotency network and genes required for lipogenesis. Our studies now show that Brd4 governs glycolysis and lipogenesis at the core of the pluripotency framework of genes and that Brd4 regulates critical nodes of metabolism leading to the production of co-factors needed for modifying the epigenome.

Related Links

Additional Information

In Campus Calendar
Yes
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
IBB, ICRC Seminar
Status
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Sep 3, 2013 - 6:50am
  • Last Updated: Apr 13, 2017 - 5:24pm