Multiscale Vascularization of Engineered 3D Tissues

Event Details
  • Date/Time:
    • Thursday February 21, 2013
      10:00 am - 11:00 am
  • Location: Whitaker 1103. Also available via video link in Emory WMB 2011.
  • Phone:
  • URL: http://www.bme.gatech.edu
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

Adrianne Proeller, adrianne.proeller@bme.gatech.edu

Faculty Host: Hanjoong Jo, hjo@emory.edu

 

Summaries

Summary Sentence: BME Faculty Candidate Seminar, Jordan S. Miller from the University of Pennsylvania Bioengineering

Full Summary: BME Faculty Candidate Jordan Miller discusses his resesarch including a new family of hydrogels he developed to better understand angiogenesis. 

The lack of sufficient numbers of donor organs for human transplantation therapies results in the loss of tens of thousands of lives and costs hundreds of billions of dollars each year in the US alone. However, the ability to create, de novo, functional organ replacements for treating human pathologies is  fundamentally limited by the lack of a comprehensive vascularization strategy for engineered three-dimensional (3D) tissues. To understand the means by which the cellular microenvironment impinges on angiogenesis – the  sprouting of new blood vessels from pre-existing ones – we developed a new family of synthetic and degradable hydrogels to tease apart interactions  between endothelial cells and the extracellular matrix (ECM) during 3D angiogenic sprouting. We show that endothelial cell sprouting requires  specific adhesive and degradable characteristics of the ECM over a narrow stiffness regime. We developed 3D printing materials and sacrificial casting strategies to enable the rapid fabrication of engineered  tissues containing perfusable vascular architectures. Patterned vasculature facilitated capillary sprouting and supported the function of primary hepatocytes in centimeter-sized constructs. Together these technologies provide a flexible platform for a wide array of specific applications, and may enable the scaling of densely populated tissue constructs to arbitrary size.

Additional Information

In Campus Calendar
Yes
Groups

Wallace H. Coulter Dept. of Biomedical Engineering

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Keywords
3d printing, bioengineering, Biology, biomedical, cardiovascular, cellular, College of Engineering; school of mechanical engineering; engineering, ECM, Research, Tissue Engineering
Status
  • Created By: Adrianne Proeller
  • Workflow Status: Published
  • Created On: Feb 13, 2013 - 11:27am
  • Last Updated: Oct 7, 2016 - 10:02pm