Neural Circuits and Synaptic Mechanosensors as Keys to Brain Repair

Event Details
  • Date/Time:
    • Tuesday November 20, 2012
      10:00 am - 11:00 am
  • Location: Molecular Science and Engineering (MoSE) Building, Rm. 1201A
  • Phone:
  • URL:
  • Email: amy.tang@bme.gatech.edu
  • Fee(s):
    N/A
  • Extras:
Contact

Amy Tang

Summaries

Summary Sentence: David F. Meaney, PhD - University of Pennsylvania

Full Summary: "Neural Circuits and Synaptic Mechanosensors as Keys to Brain Repair" - David F. Meaney, PhD - University of Pennsylvania

A seminar by

Solomon R. Pollack, PhD
Professor & Chair

Department of Bioengineering

University of Pennsylvania

Mechanical forces influence the development, maintenance, and degeneration of the nervous system at many length scales.  In this talk, we identify the molecular domains of the NMDA receptor that regulate its unique mechanosensitivity, and study how this mechanosensitivity is a key aspect that underlies the role of the NMDA receptor in traumatic brain injury (TBI).  We use imaging-based methods to study how this receptor mechanosensitivity influences the synchrony of neural circuits, and explore potential upstream therapeutic targets to reverse these mechanically-regulated changes in neural circuits. From these studies, we identify a new therapeutic target that is successful in reducing impairments in a preclinical model of TBI.

Related Links

Additional Information

In Campus Calendar
Yes
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
No audiences were selected.
Categories
Seminar/Lecture/Colloquium
Keywords
Neural Circuits and Synaptic Mechanosensors as Keys to Brain Repair
Status
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Nov 15, 2012 - 4:10am
  • Last Updated: Oct 7, 2016 - 10:01pm