{"93501":{"#nid":"93501","#data":{"type":"event","title":"(09-0219) Prof. Joan-Emma Shea, UC Santa Barbara","body":[{"value":"\u003Cp\u003EProf. Joan-Emma Shea, University of California, Santa Barbara\n\u003C\/p\u003E\n\u003Cp\u003ESimulations of protein aggregation\n\u003C\/p\u003E\n\u003Cp\u003EA number of diseases, known as amyloid diseases, are associated with pathological protein folding. In the case of Alzheimer\u0027s disease, incorrectly folded Amyloid-beta (A\u0026beta;) proteins self-assemble into a variety of neurotoxic aggregate species, ranging from small soluble oligomers to amyloid fibrils. An attractive therapeutic approach to combat amyloid diseases lies in the development of strategies to inhibit or reverse aggregation. In the first part of my talk, I will present fully atomistic molecular dynamics simulations of the interaction of aggregation inhibiting peptides with A\u0026beta; amyloid fibrils. In the second part, I will introduce a novel off-lattice coarse-grained model for the A\u0026beta; protein and discuss the kinetics and thermodynamics of aggregation and fibrillogenesis inhibition. \n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact Dr. Christine Payne, (404) 385-3125.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Prof. Joan-Emma Shea, University of California, Santa Barbara\n\nSimulations of protein aggregation","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Joan-Emma Shea, UC Santa Barbara"}],"uid":"27275","created_gmt":"2008-01-18 01:00:00","changed_gmt":"2016-10-08 01:57:24","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2009-02-19T14:00:00-05:00","event_time_end":"2009-02-19T15:00:00-05:00","event_time_end_last":"2009-02-19T15:00:00-05:00","gmt_time_start":"2009-02-19 19:00:00","gmt_time_end":"2009-02-19 20:00:00","gmt_time_end_last":"2009-02-19 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.chem.ucsb.edu\/people\/faculty\/shea\/index.shtml","title":"Prof. Joan-Emma Shea, UC Santa Barbara"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"89","name":"chemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}