{"93401":{"#nid":"93401","#data":{"type":"event","title":"(08-0218) Prof. Gianluigi Veglia, U of Minnesota","body":[{"value":"\u003Cp\u003EProf. Gianluigi Veglia, University of Minnesota\n\u003C\/p\u003E\n\u003Cp\u003EStructural Biology of Cardiac Muscle Contraction and Relaxation: From Understanding to Control\n\u003C\/p\u003E\n\u003Cp\u003ECardiac contraction and relaxation are regulated by conformational transitions of protein complexes that are responsible for calcium trafficking through cell membranes. Central to the muscle relaxation phase is a dynamic membrane protein complex formed by Ca2+-ATPase (SERCA) and phospholamban (PLN), which in humans is responsible for approximately 70% of the calcium re-uptake in the sarcoplasmic reticulum. PLN is regulated by protein kinase A (PKA), which upon adrenergic stimulation phosphorylates PLN at S16. Dysfunction in this regulatory mechanism causes severe pathophysiologies. \n\u003C\/p\u003E\n\u003Cp\u003EIn the past few years, my group has focused on the elucidation of the structure-dynamics-function correlations for the SERCA\/PLN and PKA\/PLN complexes. I will illustrate how it is possible to harness this knowledge to design new PLN mutants that can be used in gene therapy to reverse heart failure. \n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:bridgette.barry@chemistry.gatech.edu\u0022\u003EDr. Bridgette Barry\u003C\/a\u003E (404-385-6085).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Prof. Gianluigi Veglia, University of Minnesota\n\nStructural Biology of Cardiac Muscle Contraction and Relaxation: From Understanding to Control","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Gianluigi Veglia, U of Minnesota"}],"uid":"27275","created_gmt":"2008-01-28 01:00:00","changed_gmt":"2016-10-08 01:57:24","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2008-02-18T15:00:00-05:00","event_time_end":"2008-02-18T16:00:00-05:00","event_time_end_last":"2008-02-18T16:00:00-05:00","gmt_time_start":"2008-02-18 20:00:00","gmt_time_end":"2008-02-18 21:00:00","gmt_time_end_last":"2008-02-18 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.chem.umn.edu\/directory\/faculty.lasso?serial=1187","title":"Prof. Gianluigi Veglia, University of Minnesota"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"89","name":"chemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}