{"93321":{"#nid":"93321","#data":{"type":"event","title":"(08-0215) Prof. Igor Alabugin, Florida State","body":[{"value":"\u003Cp\u003EProf. Igor Alabugin, Florida State University\n\u003C\/p\u003E\n\u003Cp\u003ENew radical and photochemical reactions of alkynes\n\u003C\/p\u003E\n\u003Cp\u003EIn my talk, I will present a range of topics revolving around new reactions of alkynes. The processes are promoted by either photons or radicals and applied for preparation of interesting molecules and for inducing efficient light-activated DNA cleavage.\n\u003C\/p\u003E\n\u003Cp\u003EIn the first part, I will discuss C1C5 cyclization of enediynes and analyze how this reaction can be controlled by communication of orthogonal orbitals originating from the crossing of out-of-plane and in-plane MOs in the vicinity of the transition state. I will illustrate how this chemistry can be combined with the proper recognition elements to achieve highly efficient double stranded (ds) DNA cleavage. I will also show how ds cleavage can be amplified at the acidic pH of cancer cells and how recognition of damaged DNA can be used for the conversion of single stranded DNA damage to the ds damage. \n\u003C\/p\u003E\n\u003Cp\u003EIn the second part, I will discuss cascade radical cyclizations that utilize diaryl acetylenes in their triplet states as synthetic equivalents of 1,2-bicarbenes.  Both chemical and photophysical factors such as the involvement of \u0022phantom\u0022 excited states and the El-Sayed rules are important in directing reactivity. \n\u003C\/p\u003E\n\u003Cp\u003EIn the final part, I will present the discovery of the first efficient 5-endo-dig radical cyclization of a carbon-centered radical - a process which remained unknown despite being predicted to be favorable by the Baldwin rules about 40 years ago. \n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:uwe.bunz@chemistry.gatech.edu\u0022\u003EProf. Uwe Bunz\u003C\/a\u003E (404-385-1795).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Prof. Igor Alabugin, Florida State University\n\nNew radical and photochemical reactions of alkynes","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Igor Alabugin, Florida State"}],"uid":"27275","created_gmt":"2008-02-08 01:00:00","changed_gmt":"2016-10-08 01:57:24","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2008-02-15T14:00:00-05:00","event_time_end":"2008-02-15T15:00:00-05:00","event_time_end_last":"2008-02-15T15:00:00-05:00","gmt_time_start":"2008-02-15 19:00:00","gmt_time_end":"2008-02-15 20:00:00","gmt_time_end_last":"2008-02-15 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.chem.fsu.edu\/bio.php?id=2","title":"Prof. Igor Alabugin, Florida State University"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"6074","name":"theoretical computing"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}