{"92551":{"#nid":"92551","#data":{"type":"event","title":"(09-0302) AACP Seminar Series - Prof. David Nesbitt","body":[{"value":"\u003Cp\u003EAACP Seminar Series - Prof. David Nesbitt, JILA\/NIST University of Colorado\n\u003C\/p\u003E\n\u003Cp\u003EIn Search of Simplicity:\u003Cbr \/\u003E\nFrom Gas-Liquid Scattering to Single Molecule RNA Folding\n\u003C\/p\u003E\n\u003Cp\u003EOne of the traditions of physical chemistry is trying to break down complicated problems into simpler ones that may be more readily tested at the fundamental level by comparison between experiment and theory. This talk will address examples from our group focusing on two extremely different chemical problems. The first involves what is taking place on the molecular and quantum state level for collision dynamics at the gasliquid interface, which we study by generating supersonic beams of molecules or highly reactive radicals, \u0022bouncing\u0022 them onto freshly formed liquid surfaces in high vacuum, and probing the recoiling species with high resolution IR spectroscopy. Such data, for example, allow us to identify microscopic branching into two distinct channels: \u0022trapping-desorption\u0022 events (where molecules \u0022stick\u0022 long enough to lose their memory) and \u0022impulsive scattering\u0022 events (where molecules leave within a few collisional interactions).\n\u003C\/p\u003E\n\u003Cp\u003EThe second involves the folding kinetics and thermodynamics of small biomolecules such as RNA, which we study at the single molecule level by a sensitive combination of high numerical aperture microscopy, pulsed laser induced fluorescence and time correlated single photon counting methods. This approach permits one to \u0022watch\u0022 the folding and unfolding of a single RNA construct in real time, from which one can determine rate constants as a function of cation concentration [Mg\u003Csup\u003E+2\u003C\/sup\u003E] and thereby learn about kinetics and thermodynamics of single molecules. One particular thrust is on the temperature dependence of single molecule kinetics, which gives insight into enthalpic and entropic contributions to barriers for molecular folding and unfolding.\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:christine.payne@chemistry.gatech.edu\u0022\u003EProf. Christine Payne\u003C\/a\u003E (404-385-3125).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"AACP Seminar Series - Prof. David Nesbitt, JILA\/NIST University of Colorado\n\nIn Search of Simplicity:\nFrom Gas-Liquid Scattering to Single Molecule RNA Folding","format":"limited_html"}],"field_summary_sentence":[{"value":"AACP Seminar Series - Prof. David Nesbitt"}],"uid":"27275","created_gmt":"2008-11-17 01:00:00","changed_gmt":"2016-10-08 01:57:16","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2009-03-02T18:30:00-05:00","event_time_end":"2009-03-02T20:00:00-05:00","event_time_end_last":"2009-03-02T20:00:00-05:00","gmt_time_start":"2009-03-02 23:30:00","gmt_time_end":"2009-03-03 01:00:00","gmt_time_end_last":"2009-03-03 01:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.colorado.edu\/chemistry\/people\/nesbittd.html","title":"Prof. David Nesbitt"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"5603","name":"thesis"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1791","name":"Student sponsored"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}