{"89831":{"#nid":"89831","#data":{"type":"event","title":"(11-0314) Prof. Christopher Jaroniec, The Ohio State University","body":[{"value":"\u003Cp\u003EProf. Christopher Jaroniec, The Ohio State University\n\u003C\/p\u003E\n\u003Cp\u003EAtomic-resolution studies of protein structure and dynamics by magic-angle spinning solid-state NMR spectroscop\n\u003C\/p\u003E\n\u003Cp\u003EPhysical Chemistry Seminar Series\n\u003C\/p\u003E\n\u003Cp\u003ESolid-state nuclear magnetic resonance (SSNMR) has recently emerged as a unique spectroscopic tool, with great potential for providing atomic-resolution images of biomacromolecules that are not amenable to characterization by traditional high-resolution methods. I will discuss the basics of biomolecular magic-angle spinning SSNMR spectroscopy and describe our recent studies aimed at the detailed characterization of amyloid aggregates formed by the Y145Stop mutant of prion protein (PrP).1 This particular PrP variant is associated with the development of a heritable cerebral amyloidosis in humans, and, importantly, has been shown to provide an experimentally-tractable in vitro model for investigating the phenomena of prion strains and transmissibility barriers in mammalian prion propagation. I will also discuss our recent SSNMR studies of natively diamagnetic proteins intentionally modified with covalently-bound paramagnetic tags, including nitroxide spin labels and transition metal ions.2 The primary aim of these studies is to develop new SSNMR methodologies that exploit the nuclear paramagnetic relaxation enhancement (PRE) phenomenon to obtain long-range (up to ~20 \u00c3\u0085) structural restraints inaccessible by conventional SSNMR methods, and to utilize these PRE restraints for SSNMR protein structure refinement.\n\u003C\/p\u003E\n\u003Cp\u003E1)Helmus et al. Proc. Natl. Acad. Sci. USA 2008, 105, 6284-6289; Helmus et al. J. Am. Chem. Soc. 2010, 132, 2393-2403.\u003Cbr \/\u003E\n2)Nadaud et al. J. Am. Chem. Soc. 2007, 129, 7502-7503; Nadaud et al. J. Am. Chem. Soc. 2009, 131, 8108-8120; Nadaud et al. J. Am. Chem. Soc. 2010, 132, 9561-9563.\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:hernandez@chemistry.gatech.edu\u0022\u003EProf. Rigoberto Hernandez\u003C\/a\u003E (404-894-0594) or \u003Ca href=\u0022mailto:angelo.bongiorno@chemistry.gatech.edu\u0022\u003EProf. Angelo Bongiorno\u003C\/a\u003E (404-385-5169).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Prof. Christopher Jaroniec, The Ohio State University\n\nAtomic-resolution studies of protein structure and dynamics by magic-angle spinning solid-state NMR spectroscop\n\nPhysical Chemistry Seminar Series","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Christopher Jaroniec, The Ohio State University"}],"uid":"27275","created_gmt":"2011-01-21 01:00:00","changed_gmt":"2016-10-08 01:50:45","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-03-14T12:00:00-04:00","event_time_end":"2011-03-14T13:00:00-04:00","event_time_end_last":"2011-03-14T13:00:00-04:00","gmt_time_start":"2011-03-14 16:00:00","gmt_time_end":"2011-03-14 17:00:00","gmt_time_end_last":"2011-03-14 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.chemistry.ohio-state.edu\/department\/personnel\/faculty\/jaroniec","title":"Prof. Christopher Jaroniec, The Ohio State University"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"6942","name":"Cherry Emerson"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}