{"88741":{"#nid":"88741","#data":{"type":"event","title":"(12-0221) Prof. Steven Van Lanen, University of Kentucky","body":[{"value":"\u003Cp\u003EProf. Steven Van Lanen, University of Kentucky\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003EThe discovery and biosynthesis of highly modified nucleosides inhibiting bacterial translocase I, a novel target for antibiotics\u003C\/strong\u003E\u003C\/em\u003E\n\u003C\/p\u003E\n\u003Cp\u003EThe rapid\nincrease in multiple drug resistant bacteria has detrimentally impacted the\nclinical utility of several antibiotics, a problem that is compounded by the\nsteady decline in the FDA approval of new antibacterial drugs. We have\ndeveloped a screen aimed at identifying novel antibiotics that are inhibitors\nof a previously unexploited cellular target, bacterial translocase I, which is\nan essential enzyme involved in peptidoglycan cell wall biosynthesis. This\nscreen has led to the discovery of several uridine-based nucleoside antibiotics\nproduced by various actinomycetes. We have now identified the biosynthetic genes\nfor five of these translocase I inhibitors, and our biochemical studies have\nunearthed several interesting features including an ATP-independent mechanism\nof amide bond formation and a novel glycosylation pathway. These results, along\nwith how the biochemical knowledge has been utilized to generate novel\nanalogues, will be presented.\u003C\/p\u003E\u003Cp\u003EBiochemistry Division Seminar Series\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:wendy.kelly@chemistry.gatech.edu\u0022\u003EProf. Wendy Kelly\u003C\/a\u003E (404-385-1154).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EProf. Steven Van Lanen, University of Kentucky\n\n\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003EThe discovery and biosynthesis of highly modified nucleosides inhibiting bacterial translocase I, a novel target for antibiotics\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003EBiochemistry\/Organic Divisions Seminar Series\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Steven Van Lanen, University of Kentucky"}],"uid":"27275","created_gmt":"2011-12-07 01:00:00","changed_gmt":"2016-10-08 01:50:53","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2012-02-21T15:00:00-05:00","event_time_end":"2012-02-21T16:00:00-05:00","event_time_end_last":"2012-02-21T16:00:00-05:00","gmt_time_start":"2012-02-21 20:00:00","gmt_time_end":"2012-02-21 21:00:00","gmt_time_end_last":"2012-02-21 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/pharmacy.mc.uky.edu\/faculty\/stevenvanlanen.php","title":"Prof. Steven Van Lanen, University of Kentucky"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"919","name":"Biochemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}