{"76011":{"#nid":"76011","#data":{"type":"news","title":"Startup Receives $4 Million to Develop Drug Delivery Targeted to the Back of the Eye","body":[{"value":"\u003Cp\u003ETechnology developed by researchers at the Georgia Institute of Technology and Emory University for delivering drugs and other therapeutics to specific locations in the eye provides the foundation for a startup company that has received a $4 million venture capital investment.\u003C\/p\u003E\n\u003Cp\u003EThe Atlanta-based startup, Clearside Biomedical, plans to develop microinjection technology that will use hollow microneedles to precisely target therapeutics within the eye. If the technique proves successful in clinical trials and wins regulatory approval, it could provide an improved method for treating diseases that affect the back of the eye, including age-related macular degeneration. \n\u003C\/p\u003E\n\u003Cp\u003EThe technology was developed in collaboration between the research groups of Mark Prausnitz, a Regents\u0027 professor in Georgia Tech\u0027s School of Chemical and Biomolecular Engineering, and Henry Edelhauser, a professor in the Department of Ophthalmology at Emory School of Medicine. Research leading to development of the technology was sponsored by the National Institutes of Health (NIH).\n\u003C\/p\u003E\n\u003Cp\u003E\u0022We expect that targeting drug delivery within the eye will be helpful because we should be able to concentrate drugs at the disease sites where they need to act, and keep them away from other locations,\u0022 said Prausnitz. \u0022This could reduce side effects and possibly also decrease the dose required.\u0022\n\u003C\/p\u003E\n\u003Cp\u003EPrior to this development, drugs could be delivered to the retinal tissues at the back of the eye in three indirect ways: (1) injection by hypodermic needle into the eye\u0027s vitreous humor, the gelatinous material that fills the eyeball, (2) eye drops, which are limited in their ability to reach the back of the eye, and (3) pills taken by mouth that expose the whole body to the drug. \n\u003C\/p\u003E\n\u003Cp\u003EThe technology developed by Georgia Tech and Emory uses a hollow micron-scale needle to inject therapeutics into the suprachoroidal space located between the outer surface of the eye -- known as the sclera -- and the choroid -- a deeper layer that provides nutrients to the rest of the eye. Preclinical research has demonstrated that fluid can flow between the two layers, where it can spread out to the entire eye, including structures such as the retina that are now difficult to reach.\n\u003C\/p\u003E\n\u003Cp\u003EBy targeting this suprachoroidal space using microscopic needles, the researchers believe they can reduce trauma to the eye, make drugs more effective and reduce complications. The new delivery method could help advance a new series of drugs being developed to target the retina, choroid and other structures in the back of the eye.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022This is a significant advance in the field of ophthalmology,\u0022 said Edelhauser. \u0022Until now, it has been difficult to target drug delivery to specific locations within the eye. This new microneedle technology enables precise drug targeting to the suprachoroidal space and other locations within the eye.\u0022\n\u003C\/p\u003E\n\u003Cp\u003EIn research reported in the January 2011 issue of the journal \u003Cem\u003EPharmaceutical Research\u003C\/em\u003E, the Georgia Tech-Emory team demonstrated for the first time that this technique can be used to deliver nanoparticles and microparticles to specific parts of the eye. In later research, they also showed that microneedle injections into the suprachoroidal space rapidly resulted in concentrations of drugs and particles that could be maintained for several months.\n\u003C\/p\u003E\n\u003Cp\u003EBetween two and three million eye injections are made each year, many of them to treat age-related macular degeneration (AMD).  The researchers believe that the microneedle-based technique could be useful for treating both AMD and glaucoma, as well as other ocular conditions related to diabetes.\n\u003C\/p\u003E\n\u003Cp\u003EThe $4 million in funding for Clearside Biomedical will come from Hatteras Venture Partners, a venture capital firm based in Research Triangle Park, N.C. Hatteras focuses on seed and early-stage investments in companies developing products in biopharmaceutical, medical device, diagnostic and related human health areas.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022Clearside Biomedical represents an ideal fit for Hatteras Discovery as the platform technology is highly innovative, based on elegant science and the lead product is expected to be in clinical trials in the United States in less than 18 months,\u0022 said Christy Shaffer, Ph.D., venture partner and managing director of the Hatteras Discovery Fund.\n\u003C\/p\u003E\n\u003Cp\u003ESo far, the technique has been tested only in animals. The Hatteras funding will allow the company to conduct additional efficacy and safety testing needed to seek regulatory approval. The company\u0027s first product is expected to address macular edema and retinal vein occlusion.\n\u003C\/p\u003E\n\u003Cp\u003EClearside was formed with the assistance of Georgia Tech\u0027s VentureLab program, which helped obtain early-stage seed funding from the Georgia Research Alliance.  Georgia Tech VentureLab also helped the founders connect with the company\u0027s president and CEO, Daniel White, a veteran ophthalmic entrepreneur. Before joining Clearside, White was a co-founder of Alimera Sciences, an Atlanta company that is developing ophthalmic pharmaceuticals. \n\u003C\/p\u003E\n\u003Cp\u003ETwo researchers from the Prausnitz lab who have been involved in development of the ocular drug delivery technique will also join the company. They are Samirkumar Patel, a postdoctoral researcher and Vladimir Zarnitsyn, a research scientist.\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cem\u003EResearch leading to the development of the technology has been supported by the National Institutes of Health (NIH). The content of this article is solely the responsibility of the principal investigators and does not necessarily represent the official view of the NIH.\n\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\n\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EHenry Edelhauser, Samirkumar Patel, Mark Prausnitz, Vladimir Zarnitsyn, Emory University and Georgia Tech have financial interests in Clearside Biomedical and its ocular platform. Edelhauser, Patel, Prausnitz and Zarnitsyn own equity in Clearside and the terms of this arrangement have been reviewed and approved by Emory University or Georgia Tech in accordance with their conflict of interest policies.\u003C\/em\u003E\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EResearch News \u0026amp; Publications Office\u003Cbr \/\u003E\nGeorgia Institute of Technology\u003Cbr \/\u003E\n75 Fifth Street, N.W., Suite 314\u003Cbr \/\u003E\nAtlanta, Georgia  30308  USA\n\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\n\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMedia Relations Contacts\u003C\/strong\u003E: Georgia Tech -- John Toon (404-894-6986)(\u003Ca href=\u0022mailto:jtoon@gatech.edu\u0022\u003Ejtoon@gatech.edu\u003C\/a\u003E) or Abby Robinson (404-385-3364)(\u003Ca href=\u0022mailto:abby@innovate.gatech.edu\u0022\u003Eabby@innovate.gatech.edu\u003C\/a\u003E); Emory University -- Holly Korschun (404-727-3990)(\u003Ca href=\u0022mailto:hkorsch@emory.edu\u0022\u003Ehkorsch@emory.edu\u003C\/a\u003E).\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EWriter\u003C\/strong\u003E: John Toon\n\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003ETechnology developed by Georgia Tech and Emory University researchers for delivering drugs and other therapeutics to specific locations in the eye provides the foundation for a startup company that has received a $4 million venture capital investment.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"New technology may enable doctors to deliver drugs to the back of the eye."}],"uid":"27303","created_gmt":"2012-01-05 01:00:00","changed_gmt":"2016-10-08 03:10:53","author":"John Toon","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2012-01-05T00:00:00-05:00","iso_date":"2012-01-05T00:00:00-05:00","tz":"America\/New_York"},"extras":[],"hg_media":{"76021":{"id":"76021","type":"image","title":"Microneedle for eye injections","body":null,"created":"1449178055","gmt_created":"2015-12-03 21:27:35","changed":"1475894688","gmt_changed":"2016-10-08 02:44:48"},"76031":{"id":"76031","type":"image","title":"Microneedle for eye injection","body":null,"created":"1449178055","gmt_created":"2015-12-03 21:27:35","changed":"1475894688","gmt_changed":"2016-10-08 02:44:48"},"76041":{"id":"76041","type":"image","title":"Microneedle for eye injection","body":null,"created":"1449178055","gmt_created":"2015-12-03 21:27:35","changed":"1475894688","gmt_changed":"2016-10-08 02:44:48"}},"media_ids":["76021","76031","76041"],"related_links":[{"url":"http:\/\/www.chbe.gatech.edu\/","title":"School of Chemical \u0026 Biomolecular Engineering"},{"url":"http:\/\/www.chbe.gatech.edu\/faculty\/prausnitz.php","title":"Mark Prausnitz"}],"groups":[{"id":"1188","name":"Research Horizons"}],"categories":[{"id":"146","name":"Life Sciences and Biology"}],"keywords":[{"id":"3346","name":"drug delivery"},{"id":"495","name":"Mark Prausnitz"},{"id":"16531","name":"microinjection"},{"id":"7496","name":"microneedles"},{"id":"16521","name":"ophthalmology"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cstrong\u003EJohn Toon\u003C\/strong\u003E\u003Cbr \/\u003EResearch News \u0026amp; Publications Office\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=jt7\u0022\u003EContact John Toon\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-6986\u003C\/strong\u003E\u003C\/p\u003E","format":"limited_html"}],"email":["jtoon@gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}