{"692107":{"#nid":"692107","#data":{"type":"news","title":"Georgia Tech Researchers Discover New Layer of the Human Genome ","body":[{"value":"\u003Cdiv\u003E\u003Cp\u003EA new study led by \u003Ca href=\u0022https:\/\/people.research.gatech.edu\/francesca-storici\u0022 rel=\u0022noreferrer noopener\u0022 target=\u0022_blank\u0022\u003EFrancesca Storici\u003C\/a\u003E, a professor in the \u003Ca href=\u0022https:\/\/biosciences.gatech.edu\/\u0022 rel=\u0022noreferrer noopener\u0022 target=\u0022_blank\u0022\u003ESchool of Biological Sciences\u003C\/a\u003E and faculty member of the \u003Ca href=\u0022https:\/\/bioresearch.gatech.edu\/\u0022 rel=\u0022noreferrer noopener\u0022 target=\u0022_blank\u0022\u003EParker H. Petit Institute for Bioengineering and Bioscience\u003C\/a\u003E, has uncovered an unexpected feature of human DNA linked to gene activity and the physical organization of DNA. The findings, published in \u003Ca href=\u0022https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00922-0\u0022 rel=\u0022noreferrer noopener\u0022 target=\u0022_blank\u0022\u003E\u003Cem\u003ECell\u003C\/em\u003E\u003C\/a\u003E, could change how scientists think about DNA organization, transcription, and genome function.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EDNA and RNA are usually separate molecules inside cells, each with a different job. But small RNA building blocks, called ribonucleotides, sometimes become embedded in DNA during normal cellular activities. Scientists knew these RNA building blocks existed, but until now they did not know where they were located across the human genome or whether they served a purpose.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EStorici\u0027s team, working with collaborators at multiple institutions, created their detailed map of these RNA building blocks throughout human DNA. The researchers found that they are not randomly scattered. Instead, they are distributed in distinct patterns across the genome. The researchers call this genome-wide landscape of DNA-embedded ribonucleotides the human nuclear \u201cribome.\u201d\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003E\u201cRibonucleotides embedded in DNA have traditionally been viewed mainly as mistakes that need to be removed,\u201d Storici said. \u201cOur findings suggest a different perspective: they can influence the physical properties of DNA and may have biological functions that we are only beginning to understand.\u201d\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EThe team discovered that these embedded RNA building blocks are especially common near the starting points of active genes, where cells begin reading genetic instructions to make RNA. Their abundance also increases with gene activity. These regions experience physical stress as DNA is repeatedly accessed and used. The researchers found evidence that the embedded RNA building blocks influence how tightly the DNA twists and coils in these areas. This DNA twisting, known as supercoiling, is closely associated with transcription.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EThe findings suggest that these RNA building blocks are more than accidental leftovers from normal cellular processes. Instead, they can modulate DNA supercoiling, revealing a previously unrecognized connection between embedded ribonucleotides, DNA topology, and transcription.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003E\u201cOne of the most exciting findings is that processing ribonucleotides embedded in DNA can change DNA supercoiling,\u201d Storici said. \u201cThis provides a new connection between the chemical composition of DNA, its physical organization, and transcription.\u201d\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EThe work also may help scientists better understand diseases linked to problems removing embedded RNA from DNA, including rare autoimmune disorders. More broadly, the discovery could open a new area of investigation into the roles of embedded ribonucleotides in human genome biology.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EBy providing the first comprehensive map of these RNA marks in human nuclear DNA, the study shows that what once appeared to be simple molecular mistakes may actually contribute to how the genome is organized and functions. The discovery opens new opportunities to explore how embedded ribonucleotides influence DNA topology, transcription, and genome maintenance.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cdiv\u003EResearchers led by Francesca Storici, a professor in the School of Biological Sciences and faculty member of the Parker H. Petit Institute for Bioengineering and Bioscience, created the first comprehensive map of ribonucleotides embedded in human nuclear DNA. Published in \u003Cem\u003ECell\u003C\/em\u003E, the study found that these RNA building blocks cluster near active genes and are associated with DNA supercoiling, a physical property linked to transcription. The findings suggest that embedded ribonucleotides are not simply molecular errors but may help shape genome organization and function, opening new avenues for research into gene regulation and diseases associated with defects in ribonucleotide removal.\u003C\/div\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"A new study led by Francesca Storici reveals that RNA building blocks embedded in human DNA are organized in distinct patterns and may play an important role in regulating DNA structure and gene activity."}],"uid":"36479","created_gmt":"2026-08-28 17:05:02","changed_gmt":"2026-08-28 20:28:30","author":"abowman41","boilerplate_text":"","field_publication":"","field_article_url":"","location":"Atlanta, GA","dateline":{"date":"2026-08-28T00:00:00-04:00","iso_date":"2026-08-28T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"681002":{"id":"681002","type":"image","title":"_0000_storici-ribonucleotides.jpg","body":"\u003Cdiv\u003EScientific rendering of multiple DNA double helices with several embedded ribonucleotides highlighted in red along the strands.\u0026nbsp;\u003C\/div\u003E","created":"1787936801","gmt_created":"2026-08-28 17:06:41","changed":"1787936801","gmt_changed":"2026-08-28 17:06:41","alt":"Scientific rendering of multiple DNA double helices with several embedded ribonucleotides highlighted in red along the strands. The red RNA building blocks appear at distinct locations within the gray DNA structure, illustrating how ribonucleotides can become incorporated into human DNA.","file":{"fid":"265349","name":"_0000_storici-ribonucleotides.jpg","image_path":"\/sites\/default\/files\/2026\/08\/28\/_0000_storici-ribonucleotides.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2026\/08\/28\/_0000_storici-ribonucleotides.jpg","mime":"image\/jpeg","size":133621,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2026\/08\/28\/_0000_storici-ribonucleotides.jpg?itok=GND4O2ZW"}}},"media_ids":["681002"],"groups":[{"id":"1278","name":"College of Sciences"},{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"1188","name":"Research Horizons"},{"id":"1275","name":"School of Biological Sciences"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"}],"keywords":[{"id":"188776","name":"go-research"},{"id":"187915","name":"go-researchnews"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"}],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EAshlie Bowman | Communications Manager\u003C\/p\u003E\u003Cp\u003EParker H. Petit Institute for Bioengineering and Bioscience\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}