{"691040":{"#nid":"691040","#data":{"type":"news","title":"Researchers Develop a Safer, More Reliable Material for Growing Small-Scale Models of the Human Gut ","body":[{"value":"\u003Cdiv\u003E\u003Cp\u003EFor years, scientists studying the human gut have relied on a material that most people would never expect: a jelly made from mouse tumors. Called Matrigel, it is used to grow tiny, patient\u2011derived versions of the intestine that help researchers understand disease, test new drugs, and explore future therapies. However, since this material comes from animal tissue, it\u2019s unpredictable, difficult to control, and limits medical applications.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EA new study conducted by \u003Ca href=\u0022https:\/\/gatech.edu\/node\/1\u0022 rel=\u0022noreferrer noopener\u0022 target=\u0022_blank\u0022\u003EGeorgia Tech\u003C\/a\u003E researchers and partners from the \u003Ca href=\u0022https:\/\/www.chop.edu\/\u0022 rel=\u0022noreferrer noopener\u0022 target=\u0022_blank\u0022\u003EChildren\u2019s Hospital of Philadelphia\u003C\/a\u003E and \u003Ca href=\u0022https:\/\/www.upenn.edu\/\u0022 rel=\u0022noreferrer noopener\u0022 target=\u0022_blank\u0022\u003EUniversity of Pennsylvania\u003C\/a\u003E offers a promising alternative.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EThe work includes contributions from \u003Ca href=\u0022https:\/\/research.gatech.edu\/people\/andres-j-garcia\u0022 rel=\u0022noreferrer noopener\u0022 target=\u0022_blank\u0022\u003EAndr\u00e9s Garc\u00eda\u003C\/a\u003E, Regents\u2019 Professor in the \u003Ca href=\u0022https:\/\/www.me.gatech.edu\/\u0022 rel=\u0022noreferrer noopener\u0022 target=\u0022_blank\u0022\u003EGeorge W. Woodruff School of Mechanical Engineering\u003C\/a\u003E and Executive Director of the \u003Ca href=\u0022https:\/\/bioresearch.gatech.edu\/\u0022 rel=\u0022noreferrer noopener\u0022 target=\u0022_blank\u0022\u003EParker H. Petit Institute for Bioengineering and Bioscience\u003C\/a\u003E, whose research focuses on how engineered materials can guide cell behavior. Instead of relying on a biological mixture with hundreds of variable components, the team created a fully synthetic gel designed to give intestinal stem cells exactly what they need to grow and organize into healthy tissue.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003ETo build it, the researchers analyzed the genetic signals of human intestinal cells to understand what kind of environment they naturally prefer. They found that these cells latch onto collagen\u2011like structures and reshape their surroundings as they expand. Using that information, the team engineered a customizable gel that mimics those cues, without using any animal\u2011derived ingredients.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EThe results were striking. Human intestinal cells grown in the synthetic gel formed realistic, well\u2011organized small-scale digestive tract models that closely match those grown in the traditional animal\u2011derived material. They maintained the same cell types, developed the same structures, and preserved patient\u2011specific features.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EThe implications reach far beyond the lab bench.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EA fully synthetic, precisely defined gel means researchers can grow small-scale organs more consistently and ethically, reducing reliance on animal tissue and improving reproducibility. It also opens the door to future medical applications, from personalized drug testing to regenerative therapies, where animal\u2011based materials simply can\u2019t be used.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp lang=\u0022EN-US\u0022\u003E\u0022Reproducible, well-defined culture conditions are essential to generating reliable data from patient-derived organoids in human disease research, and we were glad to contribute to work that brings the field a real synthetic alternative to Matrigel,\u201d said Kathryn Hamilton, a co-author of the study. Hamilton is an associate professor at the \u003Ca href=\u0022https:\/\/www.upenn.edu\/\u0022 rel=\u0022noreferrer noopener\u0022 target=\u0022_blank\u0022\u003EUniversity of Pennsylvania\u003C\/a\u003E and a primary investigator at \u003Ca href=\u0022https:\/\/www.chop.edu\/\u0022 rel=\u0022noreferrer noopener\u0022 target=\u0022_blank\u0022\u003EChildren\u2019s Hospital of Philadelphia\u003C\/a\u003E. \u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EBy replacing one of the biggest barriers in organoid science, this work moves the field closer to a future where patient\u2011specific tissues can be grown safely, reliably, and at scale.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp lang=\u0022EN-US\u0022\u003E\u201cWe are excited about engineering this synthetic matrix as an alternative to natural materials and expect that it will accelerate human organoid research and clinical applications,\u201d Garc\u00eda said.\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EA new study conducted by Georgia Tech researchers and partners offers a promising alternative to gel derived from animal tissue that is currently used to grow organ models. A fully synthetic, precisely defined gel means researchers can grow small-scale organs more consistently and ethically, reducing reliance on animal tissue and improving reproducibility.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Researchers have developed a synthetic gel that could open new possibilities for drug testing and disease treatment."}],"uid":"36479","created_gmt":"2026-07-06 14:57:35","changed_gmt":"2026-07-06 15:00:23","author":"abowman41","boilerplate_text":"","field_publication":"","field_article_url":"","location":"Atlanta, GA","dateline":{"date":"2026-07-06T00:00:00-04:00","iso_date":"2026-07-06T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"680552":{"id":"680552","type":"image","title":"organoids.jpeg","body":"\u003Cp\u003EScientists are able to use patient-derived tissue samples to grow miniature versions of human organs, allowing them to test new medications and disease treatments for personalized care.\u0026nbsp;\u003C\/p\u003E","created":"1783349893","gmt_created":"2026-07-06 14:58:13","changed":"1783349893","gmt_changed":"2026-07-06 14:58:13","alt":"An image of pink mammalian tissue cells under a microscope","file":{"fid":"264828","name":"organoids.jpeg","image_path":"\/sites\/default\/files\/2026\/07\/06\/organoids.jpeg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2026\/07\/06\/organoids.jpeg","mime":"image\/jpeg","size":3590426,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2026\/07\/06\/organoids.jpeg?itok=MwjGq96r"}}},"media_ids":["680552"],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"1188","name":"Research Horizons"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"}],"keywords":[{"id":"187915","name":"go-researchnews"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"}],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EAshlie Bowman | Communications Manager\u003C\/p\u003E\u003Cp\u003EParker H. Petit Institute for Bioengineering and Bioscience\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}