{"691018":{"#nid":"691018","#data":{"type":"news","title":"New Research Seeks to Help Transplanted Cells Thrive in Type 1 Diabetes Treatment","body":[{"value":"\u003Cp\u003E\u003Ca href=\u0022https:\/\/bme.gatech.edu\/bio\/alexander-e-vlahos\u0022\u003E\u003Cstrong\u003EAlexander Vlahos\u003C\/strong\u003E\u003C\/a\u003E, assistant professor in the Wallace H. Coulter Department of Biomedical Engineering, has been awarded a five-year, research grant from \u003Ca href=\u0022https:\/\/www.breakthrought1d.org\/\u0022 rel=\u0022noopener nofollow noreferrer\u0022 target=\u0022_blank\u0022 title=\u0022(opens in a new window)\u0022\u003E\u003Cstrong\u003EBreakthrough T1D\u003C\/strong\u003E\u003C\/a\u003E, the leading global type 1 diabetes (T1D) research and advocacy organization, to support pioneering work aimed at improving therapies for T1D. The award will support Vlahos\u2019 project, \u003Cem\u003E\u201cRewiring Cellular Microenvironments with Synthetic Circuits for Subcutaneous Islet Transplantation,\u201d\u003C\/em\u003E through the Georgia Tech Research Corporation.\u003C\/p\u003E\u003Cp\u003ET1D is caused by the autoimmune destruction of insulin-producing pancreatic beta cells, requiring individuals to manage their blood glucose levels through lifelong insulin therapy. Transplanting pancreatic islets has long been investigated as a potential curative treatment, but long-lasting success in extrahepatic sites has been limited\u2014particularly when islets are transplanted beneath the skin\u2014due to poor blood vessel formation, immune rejection, and cellular stress following transplantation.\u003C\/p\u003E\u003Cp\u003EVlahos\u2019 research addresses these limitations by combining synthetic biology\u003Cstrong\u003E \u003C\/strong\u003Eand tissue engineering\u003Cstrong\u003E \u003C\/strong\u003Ein a new way: engineering cells to actively reshape their local environment after transplantation to make it more hospitable for the graft. Rather than relying solely on biomaterials or porous structures to support transplanted cells, the project focuses on programming the cells themselves to sense stress and respond dynamically.\u003C\/p\u003E\u003Cp\u003E\u003Ca href=\u0022https:\/\/bme.gatech.edu\/news\/new-research-seeks-help-transplanted-cells-thrive-type-1-diabetes-treatment\u0022\u003ERead the full story.\u003C\/a\u003E\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe award will support Vlahos\u2019 project, \u003Cem\u003E\u201cRewiring Cellular Microenvironments with Synthetic Circuits for Subcutaneous Islet Transplantation,\u201d\u003C\/em\u003E through the Georgia Tech Research Corporation. Transplanting pancreatic islets has long been investigated as a potential curative treatment, but long-lasting success in extrahepatic sites has been limited. Vlahos\u2019 research addresses existing limitations by combining synthetic biology\u003Cstrong\u003E \u003C\/strong\u003Eand tissue engineering\u003Cstrong\u003E \u003C\/strong\u003Ein a new way: engineering cells to actively reshape their local environment after transplantation to make it more hospitable for the graft.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Alexander Vlahos has been awarded a five-year, research grant to support pioneering work aimed at improving therapies for T1D."}],"uid":"36479","created_gmt":"2026-07-01 17:34:15","changed_gmt":"2026-07-01 17:39:38","author":"abowman41","boilerplate_text":"","field_publication":"","field_article_url":"","location":"Atlanta, GA","dateline":{"date":"2026-07-01T00:00:00-04:00","iso_date":"2026-07-01T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"680543":{"id":"680543","type":"image","title":"_0000_Vlahos-Blood-Glucose.jpg","body":null,"created":"1782927261","gmt_created":"2026-07-01 17:34:21","changed":"1782927261","gmt_changed":"2026-07-01 17:34:21","alt":"A medical worker wearing latex gloves uses a device to test a patient\u0027s blood sugar.","file":{"fid":"264817","name":"_0000_Vlahos-Blood-Glucose.jpg","image_path":"\/sites\/default\/files\/2026\/07\/01\/_0000_Vlahos-Blood-Glucose.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2026\/07\/01\/_0000_Vlahos-Blood-Glucose.jpg","mime":"image\/jpeg","size":76893,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2026\/07\/01\/_0000_Vlahos-Blood-Glucose.jpg?itok=MSzUqn6I"}}},"media_ids":["680543"],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"1188","name":"Research Horizons"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"},{"id":"146","name":"Life Sciences and Biology"},{"id":"135","name":"Research"}],"keywords":[{"id":"187915","name":"go-researchnews"},{"id":"171033","name":"Synthetic Biology"},{"id":"178211","name":"islet"},{"id":"49591","name":"Diabetes"},{"id":"195186","name":"cell engineering"},{"id":"1039","name":"pancreas"},{"id":"3344","name":"insulin"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"}],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EKelly Petty | Communications Manager\u003C\/p\u003E\u003Cp\u003EWallace H. Coulter Department of Biomedical Engineering\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}