{"690088":{"#nid":"690088","#data":{"type":"event","title":"BioE PhD Defense Presentation- Amisha Patel","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E: \u0026nbsp;\u003C\/p\u003E\u003Cp\u003EDr. Pamela Peralta-Yahya (School of Chemistry and Biochemistry)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee\u003C\/strong\u003E: \u0026nbsp;\u003C\/p\u003E\u003Cp\u003EDr. James C. Gumbart (School of Physics, Georgia Institute of Technology) \u0026nbsp;\u003C\/p\u003E\u003Cp\u003EDr. John Blazeck (School of Chemical and Biomolecular Engineering, Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EDr. Andrew McShan (School of Chemistry and Biochemistry, Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EDr. Corey Wilson (School of Chemical and Biomolecular Engineering, Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EImproving signal transduction of human GPCRs via yeast machinery.\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EG-Protein coupled receptors, or GPCRs, are a highly druggable class of human receptors. They constitute one of the largest and most versatile families of membrane protein that translate external stimuli into intracellular responses. This ability to detect a diverse set of ligands makes them an integral part of human pharmacology. About 30% of FDA-approved drugs target GPCR mediated pathways. They can be heterologously expressed in systems like Saccharomyces cerevisiae to develop a fast, engineerable high-throughput biosensors capable of detecting receptor-ligand interactions with applications in drug discovery and development. However, functional expression of human GPCRs in yeast, a non-native chassis, remains challenging often due to inefficient signal transduction via yeast machinery. This thesis addresses this challenge and expands the utility of yeast-based GPCR biosensors by improving GPCR-GPA1 coupling.\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Defense Presentation- \u0026nbsp;\u0022Improving signal transduction of human GPCRs via yeast machinery.\u0022 -Amisha Patel\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Improving signal transduction of human GPCRs via yeast machinery.\u0022"}],"uid":"27917","created_gmt":"2026-05-01 14:07:00","changed_gmt":"2026-05-01 14:08:30","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2026-05-05T11:00:00-04:00","event_time_end":"2026-05-05T13:00:00-04:00","event_time_end_last":"2026-05-05T13:00:00-04:00","gmt_time_start":"2026-05-05 15:00:00","gmt_time_end":"2026-05-05 17:00:00","gmt_time_end_last":"2026-05-05 17:00:00","rrule":null,"timezone":"America\/New_York"},"location":"MoSE 3201A","extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}