{"689718":{"#nid":"689718","#data":{"type":"event","title":"MS Defense by Tianyi Ye","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMaster of Science in Biology\u003C\/p\u003E\u003Cp\u003Ein the\u003C\/p\u003E\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETianyi Ye\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EWill defend his thesis\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u201cFunctional Roles of Rad52 and RPA in Inverse RNA Strand Exchange\u201d\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E22, April, 2026\u003C\/p\u003E\u003Cp\u003E10: 00 AM (EST) in EBB-1-5024.\u003C\/p\u003E\u003Cp\u003E\u003Ca href=\u0022https:\/\/nam12.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fgatech.zoom.us%2Fj%2F92351872480%3Fpwd%3D5Yq8gGcTDl5HY45siEZe6qIpwpUj8w.1\u0026amp;data=05%7C02%7Ctm186%40gtvault.onmicrosoft.com%7C0c938265c47741cfa51908de99617496%7C482198bbae7b4b258b7a6d7f32faa083%7C1%7C0%7C639116841029702073%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C\u0026amp;sdata=cWMBF3MSJkdBetWH3V9KFElL416LKPvZBSVOR7sdlGg%3D\u0026amp;reserved=0\u0022\u003Ehttps:\/\/gatech.zoom.us\/j\/92351872480?pwd=5Yq8gGcTDl5HY45siEZe6qIpwpUj8w.1\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EPasscode: \u003Cem\u003E[To be shared on the day of]\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EThesis Advisor:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EDr. Francesca Storici\u003C\/p\u003E\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EDr. Yury O. Chernoff\u003C\/p\u003E\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003EDr. Alexander Mazin\u003C\/p\u003E\u003Cp\u003EDepartment of Biochemistry and Structural Biology\u003C\/p\u003E\u003Cp\u003EUT Health San Antonio\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAbstract:\u0026nbsp;\u003C\/strong\u003ERNA-templated DNA repair has emerged as an alternative pathway for maintaining genome stability following DNA double-strand breaks (DSBs). Rad52 is a key factor in homologous recombination (HR), where it promotes strand annealing and coordinates repair intermediates. Previous in vitro studies have shown that interaction between Rad52 and replication protein A (RPA) influences inverse RNA strand exchange, a reaction in which RNA can guide DNA repair. These findings suggest a role for Rad52\u2013RPA interaction in RNA-templated DNA repair; however, whether this mechanism operates in vivo remains unclear.\u003C\/p\u003E\u003Cp\u003EIn this study, we developed a yeast-based system to investigate the role of Rad52\u2013RPA interaction in RNA-templated DNA repair. Using a chromosomal reporter assay in which restoration of gene function serves as a quantitative readout, we measured repair frequency as a proxy for inverse RNA strand exchange and evaluated Rad52 variants with disrupted RPA interaction. This approach enables direct assessment of the requirement for Rad52\u2013RPA interaction in RNA-dependent repair in vivo and provides new insight into RNA-mediated DNA repair mechanisms.\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cstrong\u003EFunctional Roles of Rad52 and RPA in Inverse RNA Strand Exchange\u003C\/strong\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Functional Roles of Rad52 and RPA in Inverse RNA Strand Exchange"}],"uid":"27707","created_gmt":"2026-04-13 18:19:55","changed_gmt":"2026-04-13 18:20:27","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2026-04-22T10:00:00-04:00","event_time_end":"2026-04-22T12:00:00-04:00","event_time_end_last":"2026-04-22T12:00:00-04:00","gmt_time_start":"2026-04-22 14:00:00","gmt_time_end":"2026-04-22 16:00:00","gmt_time_end_last":"2026-04-22 16:00:00","rrule":null,"timezone":"America\/New_York"},"location":"EBB-1-5024.","extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"111531","name":"ms defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}