{"689605":{"#nid":"689605","#data":{"type":"news","title":"Researchers Use Light to Make Their Microscopic \u2018Muscle\u2019 Contract on Command","body":[{"value":"\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cp\u003EEngineers interested in creating artificial cells to deliver drugs to unhealthy parts of the body face a key challenge: for a cell-like system to move, change shape, or divide, it needs a way to generate force on command.\u003C\/p\u003E\u003Cp\u003EBiological cells rely on adenosine triphosphate (ATP) to move muscles, transport substances across membranes, and perform other functions.\u0026nbsp;Many cellular machines couple ATP hydrolysis (a process where chemical energy stored in ATP is released) directly to motion.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EBut some single-celled organisms called ciliates use a different strategy. A pulse of calcium triggers an ultrafast contraction, and ATP is used afterward to pump calcium back into storage and reset the system.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EIn a \u003Ca href=\u0022https:\/\/www.nature.com\/articles\/s41467-026-69651-2\u0022\u003E\u003Cem\u003E\u003Cstrong\u003ENature Communications\u003C\/strong\u003E\u003C\/em\u003E\u003Cstrong\u003E study\u003C\/strong\u003E\u003C\/a\u003E led by Georgia Tech, researchers learned how to use a similar mechanism to control the movements of artificial protein networks without relying on ATP-powered motor proteins. Instead, they used calcium as a trigger to make the networks contract or relax.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201cIf engineers want synthetic cells that can do cell-like things, they need a way to generate force on command,\u201d said \u003Ca href=\u0022https:\/\/www.chbe.gatech.edu\/directory\/person\/saad-bhamla\u0022\u003E\u003Cstrong\u003ESaad Bhamla\u003C\/strong\u003E\u003C\/a\u003E, a co-author and an associate professor in Georgia Tech\u2019s \u003Ca href=\u0022https:\/\/www.chbe.gatech.edu\/\u0022\u003E\u003Cstrong\u003ESchool of Chemical and Biomolecular Engineering\u003C\/strong\u003E\u003C\/a\u003E. \u201cCells have to move, change shape, and divide. We\u2019re trying to build a controllable engine from simple parts.\u201d\u003C\/p\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cp\u003EIn the National Science Foundation-funded study, the team produced and purified \u003Cem\u003ETetrahymena thermophila\u003C\/em\u003E calcium-binding protein 2 (Tcb2), which is found in ciliates. The protein forms a fibrous network and contracts when exposed to calcium. The researchers reconstituted Tcb2 protein networks in the lab and then used a light-sensitive calcium chelator (a \u201ccage\u201d molecule that holds the calcium until illuminated) to control when and where calcium was released.\u003C\/p\u003E\u003Cp\u003EThey projected light patterns of stars and circles to prompt the network to assemble and contract in matching shapes. Then, to continuously \u201crecharge\u201d the system, the multi-university team pulsed the light on the protein networks, repeatedly releasing calcium and driving cycles of assembly and contraction.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Ca href=\u0022https:\/\/coe.gatech.edu\/news\/2026\/04\/researchers-use-light-make-their-microscopic-muscle-contract-command?utm_source=twitter\u0026amp;utm_medium=social\u0026amp;utm_campaign=news\u0022\u003ERead the full story.\u003C\/a\u003E\u003C\/p\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EIn a \u003Ca href=\u0022https:\/\/www.nature.com\/articles\/s41467-026-69651-2\u0022\u003E\u003Cem\u003E\u003Cstrong\u003ENature Communications\u003C\/strong\u003E\u003C\/em\u003E\u003Cstrong\u003E study\u003C\/strong\u003E\u003C\/a\u003E led by Georgia Tech, researchers learned how to use a similar mechanism to control the movements of artificial protein networks without relying on ATP-powered motor proteins. Instead, they used calcium as a trigger to make the networks contract or relax.\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Engineers interested in creating artificial cells to deliver drugs to unhealthy parts of the body face a key challenge: for a cell-like system to move, change shape, or divide, it needs a way to generate force on command."}],"uid":"36479","created_gmt":"2026-04-10 12:47:50","changed_gmt":"2026-04-10 12:49:38","author":"abowman41","boilerplate_text":"","field_publication":"","field_article_url":"","location":"Atlanta, GA","dateline":{"date":"2026-04-10T00:00:00-04:00","iso_date":"2026-04-10T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"679909":{"id":"679909","type":"image","title":"artificial-cells.jpg","body":null,"created":"1775825279","gmt_created":"2026-04-10 12:47:59","changed":"1775825279","gmt_changed":"2026-04-10 12:47:59","alt":"A yellow star shape is shown next to a microscope image of an artificial cell colony that has been directed to form the shape of a star.","file":{"fid":"264130","name":"artificial-cells.jpg","image_path":"\/sites\/default\/files\/2026\/04\/10\/artificial-cells.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2026\/04\/10\/artificial-cells.jpg","mime":"image\/jpeg","size":17653,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2026\/04\/10\/artificial-cells.jpg?itok=XEcClJeF"}}},"media_ids":["679909"],"related_links":[{"url":"https:\/\/coe.gatech.edu\/news\/2026\/04\/researchers-use-light-make-their-microscopic-muscle-contract-command?utm_source=twitter\u0026utm_medium=social\u0026utm_campaign=news","title":"Full Story"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"1188","name":"Research Horizons"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"}],"keywords":[{"id":"187423","name":"go-bio"},{"id":"187915","name":"go-researchnews"},{"id":"188776","name":"go-research"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"}],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EJason Maderer\u003Cbr\u003EDirector of Communications | College of Engineering\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}