{"688969":{"#nid":"688969","#data":{"type":"news","title":"Turning Carbon Into Chemistry","body":[{"value":"\u003Cp dir=\u0022ltr\u0022\u003EThe building blocks of proteins, amino acids are essential for all living things. Twenty different amino acids build the thousands of proteins that carry out biological tasks. While some are made naturally in our bodies, others are absorbed through the food we eat.\u0026nbsp;\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EAmino acids also play a critical role commercially where they are manufactured and added to pharmaceuticals, dietary supplements, cosmetics, animal feeds, and industrial chemicals \u2014 an energy-intensive process leading to greenhouse gas emissions, resource consumption, and pollution.\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EA landmark new system developed at Georgia Tech could lead to an alternative: a commercially scalable, environmentally sustainable method for amino acid production that is carbon negative, using more carbon than it emits.\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EThe breakthrough builds on\u0026nbsp;\u003Ca href=\u0022https:\/\/cos.gatech.edu\/news\/new-carbon-negative-method-produce-essential-amino-acids\u0022\u003Ea method that the team pioneered\u003C\/a\u003E in 2024 and solves a key issue \u2013 increasing efficiency to an unprecedented 97% and reducing the bioprocess cost by over 40%.\u0026nbsp;It\u2019s\u0026nbsp;the highest reported conversion of CO2 equivalents into amino acids using any synthetic biology system to date.\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EPublished in the journal\u0026nbsp;\u003Cem\u003EACS Synthetic Biology,\u0026nbsp;\u003C\/em\u003Ethe study, \u201c\u003Ca href=\u0022https:\/\/pubs.acs.org\/doi\/10.1021\/acssynbio.5c00352\u0022\u003ECell-Free-Based Thermophilic Biocatalyst for the Synthesis of Amino Acids From One-Carbon Feedstocks\u003C\/a\u003E,\u201d was led by\u0026nbsp;\u003Ca href=\u0022https:\/\/catalog.gatech.edu\/programs\/bioengineering-phd\/\u0022\u003EBioengineering\u003C\/a\u003E Ph.D. student\u0026nbsp;\u003Cstrong\u003ERay Westenberg\u0026nbsp;\u003C\/strong\u003Eand\u0026nbsp;\u003Ca href=\u0022https:\/\/peralta-yahya.gatech.edu\/\u0022\u003E\u003Cstrong\u003EProfessor Pamela Peralta-Yahya\u003C\/strong\u003E\u003C\/a\u003E, who holds joint appointments in the\u0026nbsp;\u003Ca href=\u0022https:\/\/chemistry.gatech.edu\/\u0022\u003ESchool of Chemistry and Biochemistry\u003C\/a\u003E and\u0026nbsp;\u003Ca href=\u0022https:\/\/www.chbe.gatech.edu\/\u0022\u003ESchool of Chemical and Biomolecular Engineering\u003C\/a\u003E. The team also included\u0026nbsp;\u003Cstrong\u003EShaafique Chowdhury\u003C\/strong\u003E (Ph.D. ChBE 25) and\u0026nbsp;\u003Cstrong\u003EKimberly Wennerholm\u003C\/strong\u003E (ChBE 23)\u003Cstrong\u003E;\u0026nbsp;\u003C\/strong\u003Ealongside\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003Ca href=\u0022https:\/\/www.washington.edu\/\u0022\u003EUniversity of Washington\u003C\/a\u003E collaborators\u0026nbsp;\u003Ca href=\u0022https:\/\/chainreaction.anl.gov\/ryan-cardiff\/\u0022\u003E\u003Cstrong\u003ERyan Cardiff\u003C\/strong\u003E\u003C\/a\u003E, then a Ph.D. student and now a Chain Reaction Innovations Fellow at Argonne National Laboratory, and Charles W. H. Matthaei Endowed Professor in Chemical Engineering\u0026nbsp;\u003Ca href=\u0022https:\/\/www.cheme.washington.edu\/facultyfinder\/james-carothers\u0022\u003E\u003Cstrong\u003EJames M. Carothers\u003C\/strong\u003E\u003C\/a\u003E; in addition to\u0026nbsp;Pacific Northwest National Laboratory Synthetic Biology Team Leader\u0026nbsp;\u003Ca href=\u0022https:\/\/www.pnnl.gov\/people\/alex-beliaev\u0022\u003E\u003Cstrong\u003EAlexander S. Beliaev\u003C\/strong\u003E\u003C\/a\u003E.\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003E\u0022This work shifts the narrative from simply reducing carbon emissions to actually consuming them to create value,\u201d says\u0026nbsp;Peralta-Yahya.\u0026nbsp;\u201cWe are taking low-cost carbon sources and building essential ingredients in a truly carbon-negative process that is efficient, effective, and scalable.\u201d\u003C\/p\u003E\u003Ch3 dir=\u0022ltr\u0022\u003E\u003Cstrong\u003EHeat-Loving Organisms\u003C\/strong\u003E\u003C\/h3\u003E\u003Cp dir=\u0022ltr\u0022\u003EThe work builds on the cell-free technology the team used in their earlier study. \u201cPreviously, we discovered that a system that uses the machinery of cells, without using actual living cells, could be used to create amino acids from carbon dioxide,\u201d Peralta-Yahya explains. \u201cBut to create a commercially viable system, we needed to increase the system\u2019s efficiency and reduce the cost.\u201d\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EThe team discovered that bits of leftover cells were consuming starting materials, and \u2014 like a machine with unnecessary gears or parts \u2014 this limited the system\u2019s efficiency. To optimize their \u201cmachine,\u201d the team would need to remove the extra background machinery.\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003E\u0022Leftover cell parts were using key resources without helping produce the amino acids we were looking for,\u201d says Peralta-Yahya. \u201cWe knew that heating the system could be one way to purify it because heat can denature these components.\u201d\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EThe challenge was in how to protect the essential system components from the high temperatures, she adds. \u201cWe wondered if introducing enzymes produced by a heat-loving bacterium,\u0026nbsp;\u003Cem\u003EMoorella thermoacetica,\u0026nbsp;\u003C\/em\u003Emight protect our system, while still allowing us to denature and remove that inefficient background machinery.\u201d\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EThe results were astounding: after introducing the enzymes, heating and \u201ccleaning\u201d the system, and letting it cool to room temperature, synthesis of the amino acids serine and glycine leaped to 97% yield \u2014 nearly three times that of the team\u2019s previous system.\u003C\/p\u003E\u003Ch3 dir=\u0022ltr\u0022\u003E\u003Cstrong\u003EScaling for Sustainability\u003C\/strong\u003E\u003C\/h3\u003E\u003Cp dir=\u0022ltr\u0022\u003ETo make the system viable for large-scale use, the team also needed to reduce costs. \u201cOne of the most costly components in this system is the cofactor tetrahydrofolate (THF),\u201d Peralta-Yahya shares. \u201cReducing the amount of THF needed to start the process was one way to make the system more inexpensive and ultimately more commercially viable.\u201d\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EBy linking reaction steps so waste from one step fueled the next, the team devised a method to recycle THF within the system that reduces the amount of THF needed by five-fold \u2014 lowering bioprocessing costs by 42%.\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003E\u201cThis decrease in cost and increase in yield is a critical step forward in creating a method with real potential for use in industry and manufacturing,\u201d Peralta-Yahya says. \u201cThis system could pave the way for moving this carbon-negative technology out of the lab and onto the continuous, industrial scale.\u0022\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003E\u003Cem\u003EFunding: The Advanced Research Project Agency-Energy (ARPA-E); U.S. Department of Energy; and the U.S. Department of Energy, Office of Science, Biological and Environmental Research Program.\u003C\/em\u003E\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003E\u003Cem\u003EDOI: \u003C\/em\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1021\/acssynbio.5c00352\u0022 title=\u0022DOI URL\u0022\u003E\u003Cem\u003Ehttps:\/\/doi.org\/10.1021\/acssynbio.5c00352\u003C\/em\u003E\u003C\/a\u003E\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp dir=\u0022ltr\u0022\u003EGeorgia Tech researchers have developed a breakthrough system to manufacture valuable amino acids. It\u2019s the most efficient system of its kind \u2014 and removes more carbon from the atmosphere than it emits.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Georgia Tech researchers have developed a breakthrough system to manufacture valuable amino acids. It\u2019s the most efficient system of its kind \u2014 and removes more carbon from the atmosphere than it emits."}],"uid":"35599","created_gmt":"2026-03-17 16:04:13","changed_gmt":"2026-03-25 14:16:42","author":"sperrin6","boilerplate_text":"","field_publication":"","field_article_url":"","location":"Atlanta, GA","dateline":{"date":"2026-03-17T00:00:00-04:00","iso_date":"2026-03-17T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"679657":{"id":"679657","type":"image","title":"Amino Acids","body":"\u003Cp\u003EAn illustration of a chain of amino acids forming a protein (Credit: Adobe Stock)\u003C\/p\u003E","created":"1773763467","gmt_created":"2026-03-17 16:04:27","changed":"1773763467","gmt_changed":"2026-03-17 16:04:27","alt":"Blue and orange spirals against a light blue background.","file":{"fid":"263840","name":"AdobeStock_421110334_Preview.jpeg","image_path":"\/sites\/default\/files\/2026\/03\/17\/AdobeStock_421110334_Preview.jpeg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2026\/03\/17\/AdobeStock_421110334_Preview.jpeg","mime":"image\/jpeg","size":483310,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2026\/03\/17\/AdobeStock_421110334_Preview.jpeg?itok=nVtDwueb"}}},"media_ids":["679657"],"groups":[{"id":"1278","name":"College of Sciences"},{"id":"1188","name":"Research Horizons"},{"id":"85951","name":"School of Chemistry and Biochemistry"},{"id":"660370","name":"Space"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"},{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"154","name":"Environment"},{"id":"146","name":"Life Sciences and Biology"},{"id":"194685","name":"Manufacturing"},{"id":"135","name":"Research"},{"id":"134","name":"Student and Faculty"},{"id":"8862","name":"Student Research"}],"keywords":[{"id":"187423","name":"go-bio"},{"id":"192259","name":"cos-students"},{"id":"187915","name":"go-researchnews"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"},{"id":"193653","name":"Georgia Tech Research Institute"},{"id":"39491","name":"Renewable Bioproducts"}],"news_room_topics":[{"id":"71881","name":"Science and Technology"}],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EWritten by:\u003C\/p\u003E\u003Cp\u003E\u003Ca href=\u0022mailto:sperrin6@gatech.edu\u0022\u003ESelena Langner\u003C\/a\u003E\u003Cbr\u003ECollege of Sciences\u003Cbr\u003EGeorgia Institute of Technology\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}