{"687531":{"#nid":"687531","#data":{"type":"event","title":"2026 Marcus Distinguished Lecture","body":[{"value":"\u003Cp\u003E\u003Cbr\u003E\u003Ca href=\u0022https:\/\/www.massgeneral.org\/cancer-center\/clinical-trials-and-research\/center-for-cancer-research\/investigators\/maus-lab\u0022\u003E\u003Cstrong\u003EMarcela Maus, M.D., Ph.D.\u003C\/strong\u003E\u003C\/a\u003E\u003Cbr\u003EProfessor of Medicine\u003Cbr\u003E\u003Cstrong\u003EHarvard Medical School\u003C\/strong\u003E\u003Cbr\u003EDirector, Cancer Institute Program in Cellular Immunotherapy\u003Cbr\u003EPaula J. O\u2019Keeffe Endowed Chair in Thoracic Oncology\u003Cbr\u003E\u003Cstrong\u003EMass General Brigham Cancer Institute\u003C\/strong\u003E\u003Cbr\u003E\u003Cbr\u003E\u003Cem\u003E*community lunch to follow lecture\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EBIO\u003C\/strong\u003E\u003Cbr\u003EMarcela Maus grew up in New York, NY and attended Massachusetts Institute of Technology for her undergraduate degree in Biology and Literature. She then earned her MD, PhD from the University of Pennsylvania School of Medicine where she studied the biology of human T cell activation under the direction of her PhD mentor, Dr. Carl June. After completing her doctorate degrees, Marcela did a one-year postdoctoral fellowship with Dr. Kathy High at the Children\u2019s Hospital of Philadelphia studying patient immune responses to liver-directed AAV-mediate gene transfer as a treatment for hemophilia. She then completed her clinical training in internal medicine, hematology, and oncology as a resident at the University of Pennsylvania Health System and a fellow at Memorial Sloan Kettering Cancer Center. While at Memorial Sloan Kettering, she worked in Michel Sadelain\u2019s lab to engineer new genetically modified T cells to target the cancer-testis antigen NY-ESO-1 and received specialized training in Phase I developmental therapeutics. She was also awarded a K08 grant by the NIH to facilitate her transition to a faculty position.\u003C\/p\u003E\u003Cp\u003EFollowing her extensive training (11 years), Marcela returned to the University of Pennsylvania in 2012, where she was recruited by her former PhD mentor, to expand their research efforts in the development of CAR T cells for lymphoma, myeloma, and other cancers. While there, Marcela continued her efforts on preclinical development of CAR T cells and correlative studies of CAR T cell-related toxicities and resistance to therapies. They discovered and reported on the first cases of anaphylaxis to CAR T cells and off target cross-reactivity. She also led an entire arc of translational research, from preclinical testing to a first-in-human clinical trial of EGFRvIII CAR T cells for treatment of recurrent glioblastoma. Correlative data collected from this trial led to an understanding of CAR T resistant mechanisms that have led further refinement of these CAR T cells, which is one current area of focus in her current laboratory and has led to the development of another Phase I clinical trial for GBM patients.\u003C\/p\u003E\u003Cp\u003ENow, Dr. Maus is a Professor of Hematology and Oncology at Massachusetts General Hospital and Harvard Medical School, where she runs a laboratory focused on developing and improving CAR T cell therapy for cancer patients while also periodically attending for the bone marrow transplant service. Marcela is the Paula O-Keeffe Endowed Chair of the Massachusetts General Hospital Cancer Center and the Director of the Cellular Immunotherapy Program. She has won numerous awards for her transformative research and is achieving her goal of using science to determine the best way to treat patients by harnessing the power of the immune system to solve intractable problems like cancer. She also enjoys training clinicians and scientists and watching her mentees succeed and become independent scientists and collaborators.\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EMarcela Maus, M.D., Ph.D. - Harvard Medical School, Mass General Brigham Cancer Institute\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Marcela Maus, M.D., Ph.D. - Harvard Medical School, Mass General Brigham Cancer Institute"}],"uid":"35486","created_gmt":"2026-01-21 15:04:53","changed_gmt":"2026-02-02 13:57:57","author":"Christina Wessels","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2026-10-06T11:00:00-04:00","event_time_end":"2026-10-06T13:00:00-04:00","event_time_end_last":"2026-10-06T13:00:00-04:00","gmt_time_start":"2026-10-06 15:00:00","gmt_time_end":"2026-10-06 17:00:00","gmt_time_end_last":"2026-10-06 17:00:00","rrule":null,"timezone":"America\/New_York"},"location":"Marcus Nanotechnology Building - Conference room 1116","extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[{"id":"187423","name":"go-bio"},{"id":"189814","name":"go-researchevents"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:connect@ibb.gatech.edu\u0022\u003EEvent inquiries\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}